Recognition of histone acetylation by the GAS41 YEATS domain promotes H2A.Z deposition in non-small cell lung cancer

• Published in: Genes & development Vol. 32; no. 1; pp. 58 - 69
• Main Authors: Hsu, Chih-Chao, Shi, Jiejun, Yuan, Chao, Zhao, Dan, Jiang, Shiming, Lyu, Jie, Wang, Xiaolu, Li, Haitao, Wen, Hong, Li, Wei, Shi, Xiaobing
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.01.2018
• Subjects: Acetylation; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Cell Line, Tumor; Cell Proliferation; Gene Amplification; Genes, cdc; Histones - metabolism; Histones - physiology; Humans; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Promoter Regions, Genetic; Protein Interaction Domains and Motifs; Research Paper; Transcription Factors - chemistry; Transcription Factors - genetics; Transcription Factors - metabolism; Transcription Factors - physiology; non-small cell lung cancer; GAS41; H2A.Z; YEATS domain; histone acetylation

Histone acetylation is associated with active transcription in eukaryotic cells. It helps to open up the chromatin by neutralizing the positive charge of histone lysine residues and providing binding platforms for “reader” proteins. The bromodomain (BRD) has long been thought to be the sole protein...