Macrophage Migration Inhibitory Factor Limits Renal Inflammation and Fibrosis by Counteracting Tubular Cell Cycle Arrest

• Published in: Journal of the American Society of Nephrology Vol. 28; no. 12; pp. 3590 - 3604
• Main Authors: Djudjaj, Sonja, Martin, Ina V., Buhl, Eva M., Nothofer, Nina J., Leng, Lin, Piecychna, Marta, Floege, Jürgen, Bernhagen, Jürgen, Bucala, Richard, Boor, Peter
• Format: Journal Article
• Language: English
• Published: United States American Society of Nephrology 01.12.2017
• Subjects: Animals; Apoptosis; Basic Research; Cell Cycle; Cell Proliferation; Chemokine CCL2 - metabolism; Chemokines - metabolism; Cytokines - metabolism; Female; Fibrosis - pathology; Humans; Inflammation - pathology; Intramolecular Oxidoreductases - metabolism; Kidney - metabolism; Kidney - pathology; Kidney Tubules - cytology; Kidney Tubules - pathology; Macrophage Migration-Inhibitory Factors - metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phenotype; Proto-Oncogene Proteins c-sis - metabolism; Reperfusion Injury; Transforming Growth Factor beta - metabolism; cell cycle arrest; tubular epithelium; fibrosis

Renal fibrosis is a common underlying process of progressive kidney diseases. We investigated the role of macrophage migration inhibitory factor (MIF), a pleiotropic proinflammatory cytokine, in this process. In mice subjected to unilateral ureteral obstruction, genetic deletion or pharmacologic inh...