Maturation of Luteinizing Hormone (Gonadotropin-Releasing Hormone) Secretion across Puberty: Evidence for Altered Regulation in Obese Peripubertal Girls

• Published in: The journal of clinical endocrinology and metabolism Vol. 94; no. 1; pp. 56 - 66
• Main Authors: McCartney, Christopher R., Prendergast, Kathleen A., Blank, Susan K., Helm, Kristin D., Chhabra, Sandhya, Marshall, John C.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Endocrine Society 01.01.2009; The Endocrine Society
• Subjects: Adolescent; Biological and medical sciences; Child; Cross-Sectional Studies; Endocrinopathies; Estradiol - blood; Feeding. Feeding behavior; Female; Follicle Stimulating Hormone - blood; Fundamental and applied biological sciences. Psychology; Humans; Luteinizing Hormone - secretion; Medical sciences; Obesity - metabolism; Original; Puberty - metabolism; Testosterone - blood; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Human; Obesity; Puberty; Nutrition; Secretion; Nutrition disorder; Gonadotropin RH; Metabolic diseases; Hypothalamic hormone; Regulation(control); Female; Hormone releasing factor; Child; Endocrinology; Nutritional status

Context: Peripubertal obesity (body mass index-for-age ≥ 95%) in girls is associated with hyperandrogenemia. LH likely contributes to this relationship, but overnight LH secretion in obese girls is poorly characterized. Objective: The aim of the study was to evaluate LH pulse characteristics in obes...