CD103+ CD11b+ Dendritic Cells Induce Th17 T Cells in Muc2-Deficient Mice with Extensively Spread Colitis

• Published in: PloS one Vol. 10; no. 6; p. e0130750
• Main Authors: Wenzel, Ulf A, Jonstrand, Caroline, Hansson, Gunnar C, Wick, Mary Jo
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.06.2015; Public Library of Science (PLoS)
• Subjects: Animals; Antigens; Antigens, CD - metabolism; Biochemistry; CD103 antigen; CD11 Antigens - metabolism; CD11b antigen; CD11b Antigen - metabolism; CD4 antigen; Cell Count; Cell Proliferation; Colitis - immunology; Colitis - pathology; Colon; Colon - pathology; Cytokines; Cytokines - metabolism; Dendritic cells; Dendritic Cells - immunology; Differentiation; Helper cells; Homeostasis; Immunology; Inflammation; Inflammation Mediators - metabolism; Inflammatory bowel disease; Integrin alpha Chains - metabolism; Interleukin 10; Interleukin 17; Interleukin 6; Intestine; Lymphocyte Subsets - immunology; Lymphocytes; Lymphocytes T; Mice; Mice, Inbred C57BL; Mucin-2 - deficiency; Mucin-2 - metabolism; Mucosa; Mucus; Neutrophils; Neutrophils - metabolism; Pathogenesis; Phagocytes; Rectum - pathology; Rodents; Th17 Cells - immunology; Tumor necrosis factor-α; Ulcerative colitis; γ-Interferon; Sweden

Mucus alterations are a feature of ulcerative colitis (UC) and can drive inflammation by compromising the mucosal barrier to luminal bacteria. The exact pathogenesis of UC remains unclear, but CD4+ T cells reacting to commensal antigens appear to contribute to pathology. Given the unique capacity of...