Hallmarks of a new era in mitochondrial biochemistry

• Published in: Genes & development Vol. 27; no. 24; pp. 2615 - 2627
• Main Authors: Pagliarini, David J., Rutter, Jared
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 15.12.2013
• Subjects: Animals; Cell Respiration; Humans; Mitochondria - pathology; Mitochondria - physiology; Research - trends; Review; Serial Publications - statistics & numerical data; proteomics; mitochondria; biochemistry

Stemming from the pioneering studies of bioenergetics in the 1950s, 1960s, and 1970s, mitochondria have become ingrained in the collective psyche of scientists as the “powerhouses” of the cell. While this remains a worthy moniker, more recent efforts have revealed that these organelles are home to a...