Hallmarks of a new era in mitochondrial biochemistry

Stemming from the pioneering studies of bioenergetics in the 1950s, 1960s, and 1970s, mitochondria have become ingrained in the collective psyche of scientists as the “powerhouses” of the cell. While this remains a worthy moniker, more recent efforts have revealed that these organelles are home to a...

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Published inGenes & development Vol. 27; no. 24; pp. 2615 - 2627
Main Authors Pagliarini, David J., Rutter, Jared
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 15.12.2013
Subjects
Animals
Cell Respiration
Humans
Mitochondria - pathology
Mitochondria - physiology
Research - trends
Review
Serial Publications - statistics & numerical data
proteomics
mitochondria
biochemistry
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Abstract Stemming from the pioneering studies of bioenergetics in the 1950s, 1960s, and 1970s, mitochondria have become ingrained in the collective psyche of scientists as the “powerhouses” of the cell. While this remains a worthy moniker, more recent efforts have revealed that these organelles are home to a vast array of metabolic and signaling processes and possess a proteomic landscape that is both highly varied and largely uncharted. As mitochondrial dysfunction is increasingly being implicated in a spectrum of human diseases, it is imperative that we construct a more complete framework of these organelles by systematically defining the functions of their component parts. Powerful new approaches in biochemistry and systems biology are helping to fill in the gaps.
AbstractList Stemming from the pioneering studies of bioenergetics in the 1950s, 1960s, and 1970s, mitochondria have become ingrained in the collective psyche of scientists as the "powerhouses" of the cell. While this remains a worthy moniker, more recent efforts have revealed that these organelles are home to a vast array of metabolic and signaling processes and possess a proteomic landscape that is both highly varied and largely uncharted. As mitochondrial dysfunction is increasingly being implicated in a spectrum of human diseases, it is imperative that we construct a more complete framework of these organelles by systematically defining the functions of their component parts. Powerful new approaches in biochemistry and systems biology are helping to fill in the gaps.Stemming from the pioneering studies of bioenergetics in the 1950s, 1960s, and 1970s, mitochondria have become ingrained in the collective psyche of scientists as the "powerhouses" of the cell. While this remains a worthy moniker, more recent efforts have revealed that these organelles are home to a vast array of metabolic and signaling processes and possess a proteomic landscape that is both highly varied and largely uncharted. As mitochondrial dysfunction is increasingly being implicated in a spectrum of human diseases, it is imperative that we construct a more complete framework of these organelles by systematically defining the functions of their component parts. Powerful new approaches in biochemistry and systems biology are helping to fill in the gaps.
Stemming from the pioneering studies of bioenergetics in the 1950s, 1960s, and 1970s, mitochondria have become ingrained in the collective psyche of scientists as the “powerhouses” of the cell. While this remains a worthy moniker, more recent efforts have revealed that these organelles are home to a vast array of metabolic and signaling processes and possess a proteomic landscape that is both highly varied and largely uncharted. As mitochondrial dysfunction is increasingly being implicated in a spectrum of human diseases, it is imperative that we construct a more complete framework of these organelles by systematically defining the functions of their component parts. Powerful new approaches in biochemistry and systems biology are helping to fill in the gaps.
Mitochondrial dysfunction is implicated in a spectrum of human diseases. In this review, Pagliarini and Rutter recap the discoveries that defined the core functions of mitochondria, the mitochondrial proteome, and the functions of unannotated proteins and pathways. They also offer a view of the challenges facing mitochondrial biochemists in the coming decades. Stemming from the pioneering studies of bioenergetics in the 1950s, 1960s, and 1970s, mitochondria have become ingrained in the collective psyche of scientists as the “powerhouses” of the cell. While this remains a worthy moniker, more recent efforts have revealed that these organelles are home to a vast array of metabolic and signaling processes and possess a proteomic landscape that is both highly varied and largely uncharted. As mitochondrial dysfunction is increasingly being implicated in a spectrum of human diseases, it is imperative that we construct a more complete framework of these organelles by systematically defining the functions of their component parts. Powerful new approaches in biochemistry and systems biology are helping to fill in the gaps.
Author Rutter, Jared
Pagliarini, David J.
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Issue 24
Keywords proteomics
mitochondria
biochemistry
Language English
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Snippet Stemming from the pioneering studies of bioenergetics in the 1950s, 1960s, and 1970s, mitochondria have become ingrained in the collective psyche of scientists...
Mitochondrial dysfunction is implicated in a spectrum of human diseases. In this review, Pagliarini and Rutter recap the discoveries that defined the core...
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StartPage 2615
SubjectTerms Animals
Cell Respiration
Humans
Mitochondria - pathology
Mitochondria - physiology
Research - trends
Review
Serial Publications - statistics & numerical data
Title Hallmarks of a new era in mitochondrial biochemistry
URI https://www.ncbi.nlm.nih.gov/pubmed/24352419
https://www.proquest.com/docview/1490701455
https://pubmed.ncbi.nlm.nih.gov/PMC3877752
Volume 27
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