Transient nicotine exposure in early adolescent male mice freezes their dopamine circuits in an immature state

• Published in: Nature communications Vol. 15; no. 1; pp. 9017 - 19
• Main Authors: Reynolds, Lauren M., Gulmez, Aylin, Fayad, Sophie L., Campos, Renan Costa, Rigoni, Daiana, Nguyen, Claire, Le Borgne, Tinaïg, Topilko, Thomas, Rajot, Domitille, Franco, Clara, Fernandez, Sebastian P., Marti, Fabio, Heck, Nicolas, Mourot, Alexandre, Renier, Nicolas, Barik, Jacques, Faure, Philippe
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.10.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/1689/5; 631/378/1788; 631/378/3920; 64; 64/60; 9/74; Addictions; Adolescents; Animals; Behavior, Animal - drug effects; Child development; Circuits; Development Biology; Dopamine; Dopamine - metabolism; Dopamine receptors; Dopaminergic Neurons - drug effects; Dopaminergic Neurons - metabolism; Embryology and Organogenesis; Exposure; Functional morphology; Humanities and Social Sciences; Life Sciences; Male; Males; Mice; Mice, Inbred C57BL; multidisciplinary; Neural networks; Neurobiology; Neurons and Cognition; Nicotine; Nicotine - pharmacology; Physiological responses; Science; Science (multidisciplinary); Toxicology

How nicotine acts on developing neurocircuitry in adolescence to promote later addiction vulnerability remains largely unknown, but may hold the key for informing more effective intervention efforts. We found transient nicotine exposure in early adolescent (PND 21-28) male mice was sufficient to pro...