pH-responsive gold nanoclusters-based nanoprobes for lung cancer targeted near-infrared fluorescence imaging and chemo-photodynamic therapy

• Published in: Acta biomaterialia Vol. 68; pp. 308 - 319
• Main Authors: Xia, Fangfang, Hou, Wenxiu, Zhang, Chunlei, Zhi, Xiao, Cheng, Jin, de la Fuente, Jesús M., Song, Jie, Cui, Daxiang
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2018; Elsevier BV
• Subjects: Anhydrides; Biocompatibility; Biomedical materials; Blood circulation; Cancer; Cancer therapies; Chemo-photodynamic therapy; Chlorin e6; Doxorubicin; Drug delivery; Drug delivery systems; Fluorescence; Gelatinase A; Gold; Gold nanoclusters; I.R. radiation; In vivo methods and tests; Infrared imaging; Lung cancer; MMP2 peptides; Nanoclusters; Nanoparticles; pH effects; Photodynamic therapy; Polyethylene glycol; Studies; Targeted imaging; Tumors; Chlorin e6; MMP2 peptides; Gold nanoclusters; Targeted imaging; Chemo-photodynamic therapy; Doxorubicin

[Display omitted] Nanoparticle-based drug delivery systems have drawn a great deal of attention for their opportunities to improve cancer treatments over intrinsic limits of conventional cancer therapies. Herein, we developed the polypeptide-modified gold nanoclusters (GNCs)-based nanoprobes for tum...