Phosphoproteomics of the developing heart identifies PERM1 - An outer mitochondrial membrane protein
Heart development relies on PTMs that control cardiomyocyte proliferation, differentiation and cardiac morphogenesis. We generated a map of phosphorylation sites during the early stages of cardiac postnatal development in mice; we quantified over 10,000 phosphorylation sites and 5000 proteins that w...
Saved in:
| Published in | Journal of molecular and cellular cardiology Vol. 154; pp. 41 - 59 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.05.2021
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-2828 1095-8584 1095-8584 |
| DOI | 10.1016/j.yjmcc.2021.01.010 |
Cover
| Abstract | Heart development relies on PTMs that control cardiomyocyte proliferation, differentiation and cardiac morphogenesis. We generated a map of phosphorylation sites during the early stages of cardiac postnatal development in mice; we quantified over 10,000 phosphorylation sites and 5000 proteins that were assigned to different pathways. Analysis of mitochondrial proteins led to the identification of PGC-1- and ERR-induced regulator in muscle 1 (PERM1), which is specifically expressed in skeletal muscle and heart tissue and associates with the outer mitochondrial membrane. We demonstrate PERM1 is subject to rapid changes mediated by the UPS through phosphorylation of its PEST motif by casein kinase 2. Ablation of Perm1 in mice results in reduced protein expression of lipin-1 accompanied by accumulation of specific phospholipid species. Isolation of Perm1-deficient mitochondria revealed significant downregulation of mitochondrial transport proteins for amino acids and carnitines, including SLC25A12/13/29/34 and CPT2. Consistently, we observed altered levels of various lipid species, amino acids, and acylcarnitines in Perm1−/− mitochondria. We conclude that the outer mitochondrial membrane protein PERM1 regulates homeostasis of lipid and amino acid metabolites in mitochondria.
[Display omitted]
•Proteomes from mouse hearts during early post-natal development cover >10,000 phosphorylation sites on 5000 proteins.•Skeletal muscle and heart specific PGC-1- and ERR-induced regulator in muscle 1 (PERM1) expression increases from P2 to P20•PERM1 associates with the outer mitochondrial membrane•PERM1 is regulated by phosphorylation on its PEST domain by casein kinase 2•Ablation of Perm1 alters levels of various lipid species, amino acids, and acylcarnitines |
|---|---|
| AbstractList | Heart development relies on PTMs that control cardiomyocyte proliferation, differentiation and cardiac morphogenesis. We generated a map of phosphorylation sites during the early stages of cardiac postnatal development in mice; we quantified over 10,000 phosphorylation sites and 5000 proteins that were assigned to different pathways. Analysis of mitochondrial proteins led to the identification of PGC-1- and ERR-induced regulator in muscle 1 (PERM1), which is specifically expressed in skeletal muscle and heart tissue and associates with the outer mitochondrial membrane. We demonstrate PERM1 is subject to rapid changes mediated by the UPS through phosphorylation of its PEST motif by casein kinase 2. Ablation of Perm1 in mice results in reduced protein expression of lipin-1 accompanied by accumulation of specific phospholipid species. Isolation of Perm1-deficient mitochondria revealed significant downregulation of mitochondrial transport proteins for amino acids and carnitines, including SLC25A12/13/29/34 and CPT2. Consistently, we observed altered levels of various lipid species, amino acids, and acylcarnitines in Perm1−/− mitochondria. We conclude that the outer mitochondrial membrane protein PERM1 regulates homeostasis of lipid and amino acid metabolites in mitochondria.
[Display omitted]
•Proteomes from mouse hearts during early post-natal development cover >10,000 phosphorylation sites on 5000 proteins.•Skeletal muscle and heart specific PGC-1- and ERR-induced regulator in muscle 1 (PERM1) expression increases from P2 to P20•PERM1 associates with the outer mitochondrial membrane•PERM1 is regulated by phosphorylation on its PEST domain by casein kinase 2•Ablation of Perm1 alters levels of various lipid species, amino acids, and acylcarnitines Heart development relies on PTMs that control cardiomyocyte proliferation, differentiation and cardiac morphogenesis. We generated a map of phosphorylation sites during the early stages of cardiac postnatal development in mice; we quantified over 10,000 phosphorylation sites and 5000 proteins that were assigned to different pathways. Analysis of mitochondrial proteins led to the identification of PGC-1- and ERR-induced regulator in muscle 1 (PERM1), which is specifically expressed in skeletal muscle and heart tissue and associates with the outer mitochondrial membrane. We demonstrate PERM1 is subject to rapid changes mediated by the UPS through phosphorylation of its PEST motif by casein kinase 2. Ablation of Perm1 in mice results in reduced protein expression of lipin-1 accompanied by accumulation of specific phospholipid species. Isolation of Perm1-deficient mitochondria revealed significant downregulation of mitochondrial transport proteins for amino acids and carnitines, including SLC25A12/13/29/34 and CPT2. Consistently, we observed altered levels of various lipid species, amino acids, and acylcarnitines in Perm1 mitochondria. We conclude that the outer mitochondrial membrane protein PERM1 regulates homeostasis of lipid and amino acid metabolites in mitochondria. Heart development relies on PTMs that control cardiomyocyte proliferation, differentiation and cardiac morphogenesis. We generated a map of phosphorylation sites during the early stages of cardiac postnatal development in mice; we quantified over 10,000 phosphorylation sites and 5000 proteins that were assigned to different pathways. Analysis of mitochondrial proteins led to the identification of PGC-1- and ERR-induced regulator in muscle 1 (PERM1), which is specifically expressed in skeletal muscle and heart tissue and associates with the outer mitochondrial membrane. We demonstrate PERM1 is subject to rapid changes mediated by the UPS through phosphorylation of its PEST motif by casein kinase 2. Ablation of Perm1 in mice results in reduced protein expression of lipin-1 accompanied by accumulation of specific phospholipid species. Isolation of Perm1-deficient mitochondria revealed significant downregulation of mitochondrial transport proteins for amino acids and carnitines, including SLC25A12/13/29/34 and CPT2. Consistently, we observed altered levels of various lipid species, amino acids, and acylcarnitines in Perm1-/- mitochondria. We conclude that the outer mitochondrial membrane protein PERM1 regulates homeostasis of lipid and amino acid metabolites in mitochondria.Heart development relies on PTMs that control cardiomyocyte proliferation, differentiation and cardiac morphogenesis. We generated a map of phosphorylation sites during the early stages of cardiac postnatal development in mice; we quantified over 10,000 phosphorylation sites and 5000 proteins that were assigned to different pathways. Analysis of mitochondrial proteins led to the identification of PGC-1- and ERR-induced regulator in muscle 1 (PERM1), which is specifically expressed in skeletal muscle and heart tissue and associates with the outer mitochondrial membrane. We demonstrate PERM1 is subject to rapid changes mediated by the UPS through phosphorylation of its PEST motif by casein kinase 2. Ablation of Perm1 in mice results in reduced protein expression of lipin-1 accompanied by accumulation of specific phospholipid species. Isolation of Perm1-deficient mitochondria revealed significant downregulation of mitochondrial transport proteins for amino acids and carnitines, including SLC25A12/13/29/34 and CPT2. Consistently, we observed altered levels of various lipid species, amino acids, and acylcarnitines in Perm1-/- mitochondria. We conclude that the outer mitochondrial membrane protein PERM1 regulates homeostasis of lipid and amino acid metabolites in mitochondria. |
| Author | Braun, Thomas Rugarli, Elena Trifunovic, Aleksandra Krüger, Marcus Rozsivalova, Dieu Hien Bock, Theresa Türk, Clara Krishnan, Ramesh Kumar Brodesser, Susanne Brüning, Jens König, Tim Hammerschmidt, Philipp Aravamudhan, Sriram Lang, Franziska Langer, Thomas Schindler, Natalie Nolte, Hendrik Keufgens, Lena |
| Author_xml | – sequence: 1 givenname: Sriram surname: Aravamudhan fullname: Aravamudhan, Sriram organization: Cell Signaling Technology, Dellaertweg 9b, 2316 WZ Leiden, Netherlands – sequence: 2 givenname: Clara surname: Türk fullname: Türk, Clara organization: CECAD Research Center, Institute for Genetics, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany – sequence: 3 givenname: Theresa surname: Bock fullname: Bock, Theresa organization: CECAD Research Center, Institute for Genetics, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany – sequence: 4 givenname: Lena surname: Keufgens fullname: Keufgens, Lena organization: CECAD Research Center, Institute for Genetics, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany – sequence: 5 givenname: Hendrik surname: Nolte fullname: Nolte, Hendrik organization: Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany – sequence: 6 givenname: Franziska surname: Lang fullname: Lang, Franziska organization: TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany – sequence: 7 givenname: Ramesh Kumar surname: Krishnan fullname: Krishnan, Ramesh Kumar organization: Excellence Cluster Cardio-Pulmonary Institute (CPI), Aulweg 130, 35392 Giessen, Germany – sequence: 8 givenname: Tim surname: König fullname: König, Tim organization: Montreal Neurological Institute, McGill University, 3801 University Street, H3A 2B4 Montreal, QC, Canada – sequence: 9 givenname: Philipp surname: Hammerschmidt fullname: Hammerschmidt, Philipp organization: Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany – sequence: 10 givenname: Natalie surname: Schindler fullname: Schindler, Natalie organization: Institut für Entwicklungsbiologie und Neurobiologie (IDN), Fachbereich Biologie (FB 10), Johannes Gutenberg University (JGU) Mainz, Germany c/o Institute of Molecular Biology gGmbH (IMB), Ackermannweg 4, 55128 Mainz, Germany – sequence: 11 givenname: Susanne surname: Brodesser fullname: Brodesser, Susanne organization: CECAD Research Center, Institute for Genetics, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany – sequence: 12 givenname: Dieu Hien surname: Rozsivalova fullname: Rozsivalova, Dieu Hien organization: CECAD Research Center, Institute for Genetics, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany – sequence: 13 givenname: Elena surname: Rugarli fullname: Rugarli, Elena organization: CECAD Research Center, Institute for Genetics, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany – sequence: 14 givenname: Aleksandra surname: Trifunovic fullname: Trifunovic, Aleksandra organization: CECAD Research Center, Institute for Genetics, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany – sequence: 15 givenname: Jens surname: Brüning fullname: Brüning, Jens organization: Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany – sequence: 16 givenname: Thomas surname: Langer fullname: Langer, Thomas organization: Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany – sequence: 17 givenname: Thomas surname: Braun fullname: Braun, Thomas organization: Max Planck Institute for Heart and Lung Research, Ludwigstr. 43, 61231 Bad Nauheim, Germany – sequence: 18 givenname: Marcus surname: Krüger fullname: Krüger, Marcus email: marcus.krueger@uni-koeln.de organization: CECAD Research Center, Institute for Genetics, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33549681$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkE1rGzEQQEVJaZy0v6BQdOxl3ZH2U5QeQkg_IKWh5C600mx33F3JleSA_33XcdpDLoYBXd4bSe-CnfngkbG3AtYCRPNhs95vZmvXEqRYw2HgBVsJUHXR1V11xlYAUhayk905u0hpAwCqKstX7Lws60o1nVgxdzeGtB3DNoaMYSabeBh4HpE7fMApbMn_4iOamDk59JkGwsTvbn5-F7zgV56HXcbIZ8rBjsG7SGbiM859NB7541byr9nLwUwJ3zydl-z-88399dfi9seXb9dXt4Wt6iYXvYAGsFNmcJUUpi2b1jay7-veOaFKIREr01thGuxrVK2qawvLR4Stm8G58pK9P65drv2zw5T1TMniNC1PCbukZdW1lVSg2gV994Tu-hmd3kaaTdzrf2EWoDwCNoaUIg7_EQH6kF9v9GN-fciv4TCwWOqZZSmbTMHnaGg64X46urgUeiCMOllCb9FRRJu1C3TC__jMtxN5smb6jfuT9l-ST7ZW |
| CitedBy_id | crossref_primary_10_1038_s42255_024_01196_4 crossref_primary_10_1038_s41598_022_18885_3 crossref_primary_10_1126_sciadv_abf0971 crossref_primary_10_3390_genes15101305 crossref_primary_10_1007_s11010_022_04558_2 crossref_primary_10_1016_j_jbc_2021_100825 crossref_primary_10_1039_D1MO00137J crossref_primary_10_1016_j_yjmcc_2023_12_008 crossref_primary_10_1038_s41467_021_25185_3 crossref_primary_10_3390_ijms24054692 |
| Cites_doi | 10.1016/j.celrep.2018.05.013 10.1093/emboj/18.11.2991 10.1098/rsob.170007 10.1038/ncomms6491 10.15252/embr.201745126 10.1021/acs.analchem.7b01624 10.1021/pr200092z 10.1126/science.277.5326.653 10.1038/nrd4626 10.7554/eLife.07455 10.1016/S0092-8674(00)81252-0 10.1101/gad.1661708 10.1073/pnas.091062498 10.15252/embj.201899576 10.1038/nmeth.2089 10.1016/j.cell.2010.12.001 10.1016/j.molmet.2019.02.009 10.1016/j.ajhg.2008.09.002 10.1074/jbc.M114.547448 10.1083/jcb.201404147 10.1023/A:1006891302017 10.1038/nprot.2007.261 10.1074/jbc.M113.489674 10.1242/dmm.028910 10.1161/CIRCRESAHA.115.305918 10.1126/science.2876518 10.1096/fj.02-0473rev 10.1039/c3mb25556e 10.1042/BJ20111036 10.1194/jlr.D061721 10.1074/jbc.M109.016600 10.1126/scisignal.2003506 10.1007/8904_2015_440 10.1016/j.jmb.2013.12.001 10.1016/j.cmet.2014.05.003 10.1096/fj.15-276360 10.1016/j.cell.2011.06.034 10.1038/nm.3816 10.1016/j.cmet.2006.08.005 10.1038/nprot.2006.468 10.1016/j.cell.2014.03.032 10.1097/FJC.0b013e3181e74a14 10.1111/febs.14854 10.1074/jbc.274.32.22184 10.1371/journal.pone.0234913 10.1016/j.celrep.2012.07.006 10.1006/geno.1999.6023 10.1038/nprot.2006.62 10.1021/pr101065j 10.1016/j.tibs.2019.11.001 10.1016/j.jprot.2015.03.028 10.1038/nature22978 10.1073/pnas.222561499 10.1016/j.cardfail.2006.03.002 10.1038/nature15372 10.1016/j.cell.2008.05.033 10.1016/j.yjmcc.2011.04.009 10.1016/S0968-0004(96)10031-1 10.1073/pnas.0701078104 10.1038/s41598-018-31154-6 10.1371/journal.pone.0223024 10.1016/S0022-2275(20)32011-3 10.1080/07435800.2018.1474920 10.1038/s41467-018-06519-0 10.1038/nbt.1511 10.1083/jcb.93.1.97 10.1038/nmeth.1322 10.1016/j.str.2005.11.012 10.1113/jphysiol.2010.189670 10.1016/j.chroma.2016.04.006 |
| ContentType | Journal Article |
| Copyright | 2021 The Author(s) Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved. |
| Copyright_xml | – notice: 2021 The Author(s) – notice: Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved. |
| DBID | 6I. AAFTH AAYXX CITATION NPM 7X8 |
| DOI | 10.1016/j.yjmcc.2021.01.010 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1095-8584 |
| EndPage | 59 |
| ExternalDocumentID | 33549681 10_1016_j_yjmcc_2021_01_010 S0022282821000250 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M .1- .55 .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 29L 3O- 4.4 457 4G. 53G 5GY 5VS 7-5 71M 8P~ 9JM AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAXKI AAXUO AAYWO ABBQC ABFNM ABFRF ABGSF ABJNI ABLJU ABMAC ABMZM ABUDA ABWVN ABXDB ACDAQ ACGFO ACGFS ACIEU ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADFGL ADMUD ADNMO ADUVX AEBSH AEFWE AEIPS AEKER AENEX AEUPX AEVXI AFJKZ AFPUW AFRHN AFTJW AFXIZ AGCQF AGHFR AGQPQ AGRDE AGUBO AGYEJ AHHHB AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CAG COF CS3 DM4 DU5 EBS EFBJH EFKBS EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEB HLW HMK HMO HVGLF HZ~ IHE J1W K-O KOM L7B LX2 M29 M41 MO0 N9A O-L O9- OAUVE OA~ OL0 OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SAE SBG SCC SDF SDG SDP SEL SES SEW SPCBC SSH SSZ T5K WUQ X7M XPP Z5R ZGI ZMT ZU3 ~G- 6I. AACTN AAFTH AAIAV ABLVK ABYKQ AEHWI AFKWA AHPSJ AJBFU AJOXV AMFUW DOVZS EFLBG LCYCR RIG SSU AAYXX AFCTW AGRNS CITATION NPM 7X8 |
| ID | FETCH-LOGICAL-c456t-b1060e89afd421a7367c62bb5bdd19312ee4abc1a6eb5e97955c05491c56fdd3 |
| IEDL.DBID | AIKHN |
| ISSN | 0022-2828 1095-8584 |
| IngestDate | Thu Sep 04 23:41:46 EDT 2025 Mon Jul 21 05:56:01 EDT 2025 Thu Apr 24 22:59:55 EDT 2025 Tue Jul 01 04:05:31 EDT 2025 Fri Feb 23 02:46:18 EST 2024 Tue Aug 26 17:12:02 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | ETS AMD1 SCX SLC TFA 4EBP1 Mitochondria TBB SDH Lipid metabolism MKL2 DGC Heart development H&E IAA IT ER NCE MAM ROX TiO2 NO PECAM-1 ABC DTT PERM1 PTM FCCP CK2 FSTL1 CLPTM1 MFN2 fld Phosphoproteomics BAC BN-PAGE IKK SILAC DAG ACN ECM NMM S6K1 PA CaMKII PE MCM FASP PI LPIN1 PAP PF4 |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c456t-b1060e89afd421a7367c62bb5bdd19312ee4abc1a6eb5e97955c05491c56fdd3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0022282821000250 |
| PMID | 33549681 |
| PQID | 2487429097 |
| PQPubID | 23479 |
| PageCount | 19 |
| ParticipantIDs | proquest_miscellaneous_2487429097 pubmed_primary_33549681 crossref_primary_10_1016_j_yjmcc_2021_01_010 crossref_citationtrail_10_1016_j_yjmcc_2021_01_010 elsevier_sciencedirect_doi_10_1016_j_yjmcc_2021_01_010 elsevier_clinicalkey_doi_10_1016_j_yjmcc_2021_01_010 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | May 2021 2021-05-00 20210501 |
| PublicationDateYYYYMMDD | 2021-05-01 |
| PublicationDate_xml | – month: 05 year: 2021 text: May 2021 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Journal of molecular and cellular cardiology |
| PublicationTitleAlternate | J Mol Cell Cardiol |
| PublicationYear | 2021 |
| Publisher | Elsevier Ltd |
| Publisher_xml | – name: Elsevier Ltd |
| References | Thangaratnarajah, Ruprecht, Kunji (bb0245) 2014; 5 Garcia-Alai, Gallo, Salame, Wetzler, McBride, Paci, Cicero, de Prat-Gay (bb0100) 2006; 14 Cho, Tachibana, Hazen, Moresco, Yates, Kok, Saez, Ross, Russell, Kralli (bb0125) 2019; 23 Mitra, Schilling, Wang, Jay, Huss, Su, Finck (bb0145) 2011; 51 Rashid, Nemazanyy, Paolini, Tatsuta, Crespin, de Villeneuve, Brodesser, Benit, Rustin, Baraibar, Agbulut, Olivier, Protasi, Langer, Chrast, de Lonlay, de Foucauld, Blaauw, Pende (bb0230) 2019; 38 Krüger, Moser, Ussar, Thievessen, Luber, Forner, Schmidt, Zanivan, Fässler, Mann (bb0265) 2008; 134 Tusher, Tibshirani, Chu (bb0295) 2001; 98 Cox, Mann (bb0285) 2008; 26 Rundqvist, Montelius, Osterlund, Norman, Esbjornsson, Jansson (bb0130) 2019; 14 Schweitzer, Collier, Chen, Eaton, Connolly, Bucelli, Pestronk, Harris, Finck (bb0210) 2015; 23 Rappsilber, Mann, Ishihama (bb0275) 2007; 2 Nemoto, De Camilli (bb0305) 1999; 18 Koser, Loescher, Linke (bb0055) 2019; 286 Schild, Ruhs, Beiter, Zugel, Hudemann, Reimer, Krumholz-Wagner, Wagner, Keller, Eder, Kruger, Kruger, Braun, Niess, Steinacker, Mooren (bb0120) 2015; 122 Lai, Leone, Zechner, Schaeffer, Kelly, Flanagan, Medeiros, Kovacs, Kelly (bb0045) 2008; 22 Wang, Li, Hockemeyer, Sutherland, Wang, Schratt, Richardson, Nordheim, Olson (bb0060) 2002; 99 Shevchenko, Tomas, Havlis, Olsen, Mann (bb0270) 2006; 1 Becker, Kukat, Szczepanowska, Hermans, Senft, Brandscheid, Maiti, Trifunovic (bb0335) 2018; 19 Peterfy, Phan, Oswell, Xu, Reue (bb0205) 1999; 62 Peterson, Sengupta, Harris, Carmack, Kang, Balderas, Guertin, Madden, Carpenter, Finck, Sabatini (bb0235) 2011; 146 Nolte, MacVicar, Tellkamp, Kruger (bb0300) 2018; 8 Kozjak-Pavlovic, Prell, Thiede, Götz, Wosiek, Ott, Rudel (bb0320) 2014; 426 Glass, Bowen, Stitt, Radziejewski, Bruno, Ryan, Gies, Shah, Mattsson, Burden, DiStefano, Valenzuela, DeChiara, Yancopoulos (bb0075) 1996; 85 Lopaschuk, Spafford, Marsh (bb0040) 1991; 261 Meggio, Pinna (bb0090) 2003; 17 Lundby, Lage, Weinert, Bekker-Jensen, Secher, Skovgaard, Kelstrup, Dmytriyev, Choudhary, Lundby, Olsen (bb0025) 2012; 2 Lopaschuk, Jaswal (bb0035) 2010; 56 Lin, Yee, Kim, Giacomini (bb0155) 2015; 14 Wei, Serpooshan, Hurtado, Diez-Cunado, Zhao, Maruyama, Zhu, Fajardo, Noseda, Nakamura, Tian, Liu, Wang, Matsuura, Bushway, Cai, Savchenko, Mahmoudi, Schneider, van den Hoff, Butte, Yang, Walsh, Zhou, Bernstein, Mercola, Ruiz-Lozano (bb0180) 2015; 525 Wittig, Braun, Schagger (bb0340) 2006; 1 Oka, Sabry, Horiuchi, Cawley, O'Very, Zaitsev, Shankar, Byun, Mukai, Xu, Torres, Kumar, Yazawa, Ling, Taleb, Saijoh, Drakos, Sadoshima, Warren (bb0185) 2020; 15 Ruprecht, Kunji (bb0240) 2020; 45 Zarei, Sprenger, Metzger, Gretzmeier, Dengjel (bb0020) 2011; 10 Bragoszewski, Turek, Chacinska (bb0195) 2017; 7 Cho, Hazen, Gandra, Ward, Schenk, Russell, Kralli (bb0115) 2016; 30 Cho, Hazen, Russell, Kralli (bb0200) 2013; 288 Zhang, Verity, Reue (bb0220) 2014; 20 Wong, Malec, Mabrouk, Ro, Dus, Kennedy (bb0355) 2016; 1446 Palmieri, Vozza, Agrimi, De Marco, Runswick, Palmieri, Walker (bb0165) 1999; 274 Huttlin, Jedrychowski, Elias, Goswami, Rad, Beausoleil, Villen, Haas, Sowa, Gygi (bb0010) 2010; 143 Raju, Kakkar, Radhi, Sharma (bb0015) 1997; 176 Rechsteiner, Rogers (bb0085) 1996; 21 Fujiki, Hubbard, Fowler, Lazarow (bb0315) 1982; 93 Yahalom-Ronen, Rajchman, Sarig, Geiger, Tzahor (bb0070) 2015; 4 Cox, Neuhauser, Michalski, Scheltema, Olsen, Mann (bb0290) 2011; 10 Lörchner, Pöling, Gajawada, Hou, Polyakova, Kostin, Adrian-Segarra, Boettger, Wietelmann, Warnecke (bb0325) 2015; 21 Schneider, Rasband, Eliceiri (bb0330) 2012; 9 Puente, Kimura, Muralidhar, Moon, Amatruda, Phelps, Grinsfelder, Rothermel, Chen, Garcia, Santos, Thet, Mori, Kinter, Rindler, Zacchigna, Mukherjee, Chen, Mahmoud, Giacca, Rabinovitch, Aroumougame, Shah, Szweda, Sadek (bb0005) 2014; 157 Cho, Hazen, Russell, Kralli (bb0050) 2013; 288 Reue, Xu, Wang, Slavin (bb0140) 2000; 41 Kumar, Bouameur, Bar, Rice, Hornig-Do, Roop, Schwarz, Brodesser, Thiering, Leube, Wiesner, Vijayaraj, Brazel, Heller, Binder, Loffler-Wirth, Seibel, Magin (bb0345) 2015; 211 Fornasiero, Mandad, Wildhagen, Alevra, Rammner, Keihani, Opazo, Urban, Ischebeck, Sakib, Fard, Kirli, Centeno, Vidal, Rahman, Benito, Fischer, Dennerlein, Rehling, Feussner, Bonn, Simons, Urlaub, Rizzoli (bb0105) 2018; 9 Finck, Gropler, Chen, Leone, Croce, Harris, Lawrence, Kelly (bb0150) 2006; 4 Giesbertz, Ecker, Haag, Spanier, Daniel (bb0360) 2015; 56 Dobreva, Braun (bb0080) 2015; 116 Pohjoismaki, Kruger, Al-Furoukh, Lagerstedt, Karhunen, Braun (bb0170) 2013; 9 Pohjoismäki, Goffart, Tyynismaa, Willcox, Ide, Kang, Suomalainen, Karhunen, Griffith, Holt (bb0310) 2009; 284 Yoon, Zhang, Pain, Lyver, Lesuisse, Pain, Dancis (bb0250) 2011; 440 Porcelli, Fiermonte, Longo, Palmieri (bb0160) 2014; 289 Bassat, Mutlak, Genzelinakh, Shadrin, Baruch Umansky, Yifa, Kain, Rajchman, Leach, Riabov Bassat, Udi, Sarig, Sagi, Martin, Bursac, Cohen, Tzahor (bb0065) 2017; 547 Wisniewski, Zougman, Nagaraj, Mann (bb0280) 2009; 6 Buerger, Rozhitskaya, Sherwood, Dorfman, Bisping, Abel, Pu, Izumo, Jay (bb0225) 2006; 12 Rogers, Wells, Rechsteiner (bb0095) 1986; 234 Brinkmann, Kuckertz, Schiffer, Bloch, Predel, Brixius (bb0135) 2019; 44 Lundby, Andersen, Steffensen, Horn, Kelstrup, Francavilla, Jensen, Schmitt, Thomsen, Olsen (bb0030) 2013; 6 Lavie, De Belvalet, Sonon, Ion, Dumon, Melser, Lacombe, Dupuy, Lalou, Benard (bb0190) 2018; 23 Wiley, Murphy, Ross, van der Geer, Dixon (bb0260) 2007; 104 Lang, Aravamudhan, Nolte, Turk, Holper, Muller, Gunther, Blaauw, Braun, Kruger (bb0110) 2017; 10 Piquereau, Novotova, Fortin, Garnier, Ventura-Clapier, Veksler, Joubert (bb0175) 2010; 588 Beinert, Holm, Munck (bb0255) 1997; 277 Zeharia, Shaag, Houtkooper, Hindi, de Lonlay, Erez, Hubert, Saada, de Keyzer, Eshel, Vaz, Pines, Elpeleg (bb0215) 2008; 83 Schwaiger, Rampler, Hermann, Miklos, Berger, Koellensperger (bb0350) 2017; 89 Rechsteiner (10.1016/j.yjmcc.2021.01.010_bb0085) 1996; 21 Pohjoismaki (10.1016/j.yjmcc.2021.01.010_bb0170) 2013; 9 Raju (10.1016/j.yjmcc.2021.01.010_bb0015) 1997; 176 Nemoto (10.1016/j.yjmcc.2021.01.010_bb0305) 1999; 18 Palmieri (10.1016/j.yjmcc.2021.01.010_bb0165) 1999; 274 Schwaiger (10.1016/j.yjmcc.2021.01.010_bb0350) 2017; 89 Huttlin (10.1016/j.yjmcc.2021.01.010_bb0010) 2010; 143 Glass (10.1016/j.yjmcc.2021.01.010_bb0075) 1996; 85 Rundqvist (10.1016/j.yjmcc.2021.01.010_bb0130) 2019; 14 Wiley (10.1016/j.yjmcc.2021.01.010_bb0260) 2007; 104 Dobreva (10.1016/j.yjmcc.2021.01.010_bb0080) 2015; 116 Cho (10.1016/j.yjmcc.2021.01.010_bb0200) 2013; 288 Cox (10.1016/j.yjmcc.2021.01.010_bb0285) 2008; 26 Pohjoismäki (10.1016/j.yjmcc.2021.01.010_bb0310) 2009; 284 Beinert (10.1016/j.yjmcc.2021.01.010_bb0255) 1997; 277 Lopaschuk (10.1016/j.yjmcc.2021.01.010_bb0035) 2010; 56 Becker (10.1016/j.yjmcc.2021.01.010_bb0335) 2018; 19 Buerger (10.1016/j.yjmcc.2021.01.010_bb0225) 2006; 12 Krüger (10.1016/j.yjmcc.2021.01.010_bb0265) 2008; 134 Wisniewski (10.1016/j.yjmcc.2021.01.010_bb0280) 2009; 6 Lundby (10.1016/j.yjmcc.2021.01.010_bb0025) 2012; 2 Lopaschuk (10.1016/j.yjmcc.2021.01.010_bb0040) 1991; 261 Oka (10.1016/j.yjmcc.2021.01.010_bb0185) 2020; 15 Bassat (10.1016/j.yjmcc.2021.01.010_bb0065) 2017; 547 Ruprecht (10.1016/j.yjmcc.2021.01.010_bb0240) 2020; 45 Brinkmann (10.1016/j.yjmcc.2021.01.010_bb0135) 2019; 44 Cox (10.1016/j.yjmcc.2021.01.010_bb0290) 2011; 10 Yoon (10.1016/j.yjmcc.2021.01.010_bb0250) 2011; 440 Peterson (10.1016/j.yjmcc.2021.01.010_bb0235) 2011; 146 Bragoszewski (10.1016/j.yjmcc.2021.01.010_bb0195) 2017; 7 Rogers (10.1016/j.yjmcc.2021.01.010_bb0095) 1986; 234 Rashid (10.1016/j.yjmcc.2021.01.010_bb0230) 2019; 38 Giesbertz (10.1016/j.yjmcc.2021.01.010_bb0360) 2015; 56 Cho (10.1016/j.yjmcc.2021.01.010_bb0115) 2016; 30 Schneider (10.1016/j.yjmcc.2021.01.010_bb0330) 2012; 9 Wei (10.1016/j.yjmcc.2021.01.010_bb0180) 2015; 525 Lang (10.1016/j.yjmcc.2021.01.010_bb0110) 2017; 10 Porcelli (10.1016/j.yjmcc.2021.01.010_bb0160) 2014; 289 Piquereau (10.1016/j.yjmcc.2021.01.010_bb0175) 2010; 588 Fornasiero (10.1016/j.yjmcc.2021.01.010_bb0105) 2018; 9 Zarei (10.1016/j.yjmcc.2021.01.010_bb0020) 2011; 10 Rappsilber (10.1016/j.yjmcc.2021.01.010_bb0275) 2007; 2 Yahalom-Ronen (10.1016/j.yjmcc.2021.01.010_bb0070) 2015; 4 Finck (10.1016/j.yjmcc.2021.01.010_bb0150) 2006; 4 Wittig (10.1016/j.yjmcc.2021.01.010_bb0340) 2006; 1 Tusher (10.1016/j.yjmcc.2021.01.010_bb0295) 2001; 98 Fujiki (10.1016/j.yjmcc.2021.01.010_bb0315) 1982; 93 Lundby (10.1016/j.yjmcc.2021.01.010_bb0030) 2013; 6 Kumar (10.1016/j.yjmcc.2021.01.010_bb0345) 2015; 211 Puente (10.1016/j.yjmcc.2021.01.010_bb0005) 2014; 157 Lai (10.1016/j.yjmcc.2021.01.010_bb0045) 2008; 22 Cho (10.1016/j.yjmcc.2021.01.010_bb0125) 2019; 23 Meggio (10.1016/j.yjmcc.2021.01.010_bb0090) 2003; 17 Peterfy (10.1016/j.yjmcc.2021.01.010_bb0205) 1999; 62 Zeharia (10.1016/j.yjmcc.2021.01.010_bb0215) 2008; 83 Reue (10.1016/j.yjmcc.2021.01.010_bb0140) 2000; 41 Nolte (10.1016/j.yjmcc.2021.01.010_bb0300) 2018; 8 Wong (10.1016/j.yjmcc.2021.01.010_bb0355) 2016; 1446 Lavie (10.1016/j.yjmcc.2021.01.010_bb0190) 2018; 23 Zhang (10.1016/j.yjmcc.2021.01.010_bb0220) 2014; 20 Shevchenko (10.1016/j.yjmcc.2021.01.010_bb0270) 2006; 1 Garcia-Alai (10.1016/j.yjmcc.2021.01.010_bb0100) 2006; 14 Cho (10.1016/j.yjmcc.2021.01.010_bb0050) 2013; 288 Schweitzer (10.1016/j.yjmcc.2021.01.010_bb0210) 2015; 23 Lörchner (10.1016/j.yjmcc.2021.01.010_bb0325) 2015; 21 Mitra (10.1016/j.yjmcc.2021.01.010_bb0145) 2011; 51 Thangaratnarajah (10.1016/j.yjmcc.2021.01.010_bb0245) 2014; 5 Wang (10.1016/j.yjmcc.2021.01.010_bb0060) 2002; 99 Kozjak-Pavlovic (10.1016/j.yjmcc.2021.01.010_bb0320) 2014; 426 Schild (10.1016/j.yjmcc.2021.01.010_bb0120) 2015; 122 Koser (10.1016/j.yjmcc.2021.01.010_bb0055) 2019; 286 Lin (10.1016/j.yjmcc.2021.01.010_bb0155) 2015; 14 |
| References_xml | – volume: 234 start-page: 364 year: 1986 end-page: 368 ident: bb0095 article-title: Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis publication-title: Science – volume: 9 start-page: 1210 year: 2013 end-page: 1219 ident: bb0170 article-title: Postnatal cardiomyocyte growth and mitochondrial reorganization cause multiple changes in the proteome of human cardiomyocytes publication-title: Mol. BioSyst. – volume: 19 year: 2018 ident: bb0335 article-title: CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis publication-title: EMBO Rep. – volume: 22 start-page: 1948 year: 2008 end-page: 1961 ident: bb0045 article-title: Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart publication-title: Genes Dev. – volume: 99 start-page: 14855 year: 2002 end-page: 14860 ident: bb0060 article-title: Potentiation of serum response factor activity by a family of myocardin-related transcription factors publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 2 start-page: 419 year: 2012 end-page: 431 ident: bb0025 article-title: Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns publication-title: Cell Rep. – volume: 286 start-page: 2240 year: 2019 end-page: 2260 ident: bb0055 article-title: Posttranslational modifications of titin from cardiac muscle: how, where, and what for? publication-title: FEBS J. – volume: 261 start-page: H1698 year: 1991 end-page: H1705 ident: bb0040 article-title: Glycolysis is predominant source of myocardial ATP production immediately after birth publication-title: Am. J. Phys. Heart Circ. Phys. – volume: 7 year: 2017 ident: bb0195 article-title: Control of mitochondrial biogenesis and function by the ubiquitin-proteasome system publication-title: Open Biol. – volume: 38 year: 2019 ident: bb0230 article-title: Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy publication-title: EMBO J. – volume: 21 start-page: 267 year: 1996 end-page: 271 ident: bb0085 article-title: PEST sequences and regulation by proteolysis publication-title: Trends Biochem. Sci. – volume: 211 start-page: 1057 year: 2015 end-page: 1075 ident: bb0345 article-title: A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity publication-title: J. Cell Biol. – volume: 176 start-page: 135 year: 1997 end-page: 143 ident: bb0015 article-title: Biological significance of phosphorylation and myristoylation in the regulation of cardiac muscle proteins publication-title: Mol. Cell. Biochem. – volume: 17 start-page: 349 year: 2003 end-page: 368 ident: bb0090 article-title: One-thousand-and-one substrates of protein kinase CK2? publication-title: FASEB J. – volume: 288 start-page: 25207 year: 2013 end-page: 25218 ident: bb0200 article-title: Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells publication-title: J. Biol. Chem. – volume: 85 start-page: 513 year: 1996 end-page: 523 ident: bb0075 article-title: Agrin acts via a MuSK receptor complex publication-title: Cell – volume: 284 start-page: 21446 year: 2009 end-page: 21457 ident: bb0310 article-title: Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks publication-title: J. Biol. Chem. – volume: 122 start-page: 119 year: 2015 end-page: 132 ident: bb0120 article-title: Basal and exercise induced label-free quantitative protein profiling of m. vastus lateralis in trained and untrained individuals publication-title: J. Proteome – volume: 1 start-page: 2856 year: 2006 end-page: 2860 ident: bb0270 article-title: In-gel digestion for mass spectrometric characterization of proteins and proteomes publication-title: Nat. Protoc. – volume: 9 start-page: 671 year: 2012 end-page: 675 ident: bb0330 article-title: NIH image to ImageJ: 25 years of image analysis publication-title: Nat. Methods – volume: 146 start-page: 408 year: 2011 end-page: 420 ident: bb0235 article-title: mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway publication-title: Cell – volume: 18 start-page: 2991 year: 1999 end-page: 3006 ident: bb0305 article-title: Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein publication-title: EMBO J. – volume: 89 start-page: 7667 year: 2017 end-page: 7674 ident: bb0350 article-title: Anion-exchange chromatography coupled to high-resolution mass spectrometry: a powerful tool for merging targeted and non-targeted metabolomics publication-title: Anal. Chem. – volume: 14 start-page: 309 year: 2006 end-page: 319 ident: bb0100 article-title: Molecular basis for phosphorylation-dependent, PEST-mediated protein turnover publication-title: Structure – volume: 4 year: 2015 ident: bb0070 article-title: Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion publication-title: Elife – volume: 116 start-page: 767 year: 2015 end-page: 769 ident: bb0080 article-title: The transcriptional landscape of regenerating newborn mouse hearts publication-title: Circ. Res. – volume: 93 start-page: 97 year: 1982 end-page: 102 ident: bb0315 article-title: Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum publication-title: J. Cell Biol. – volume: 143 start-page: 1174 year: 2010 end-page: 1189 ident: bb0010 article-title: A tissue-specific atlas of mouse protein phosphorylation and expression publication-title: Cell – volume: 6 year: 2013 ident: bb0030 article-title: In vivo phosphoproteomics analysis reveals the cardiac targets of beta-adrenergic receptor signaling publication-title: Sci. Signal. – volume: 98 start-page: 5116 year: 2001 end-page: 5121 ident: bb0295 article-title: Significance analysis of microarrays applied to the ionizing radiation response publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 5 start-page: 5491 year: 2014 ident: bb0245 article-title: Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers publication-title: Nat. Commun. – volume: 274 start-page: 22184 year: 1999 end-page: 22190 ident: bb0165 article-title: Identification of the yeast mitochondrial transporter for oxaloacetate and sulfate publication-title: J. Biol. Chem. – volume: 134 start-page: 353 year: 2008 end-page: 364 ident: bb0265 article-title: SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function publication-title: Cell – volume: 157 start-page: 565 year: 2014 end-page: 579 ident: bb0005 article-title: The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response publication-title: Cell – volume: 14 start-page: 543 year: 2015 end-page: 560 ident: bb0155 article-title: SLC transporters as therapeutic targets: emerging opportunities publication-title: Nat. Rev. Drug Discov. – volume: 10 start-page: 1794 year: 2011 end-page: 1805 ident: bb0290 article-title: Andromeda: a peptide search engine integrated into the MaxQuant environment publication-title: J. Proteome Res. – volume: 10 start-page: 3474 year: 2011 end-page: 3483 ident: bb0020 article-title: Comparison of ERLIC-TiO2, HILIC-TiO2, and SCX-TiO2 for global phosphoproteomics approaches publication-title: J. Proteome Res. – volume: 10 start-page: 881 year: 2017 end-page: 896 ident: bb0110 article-title: Dynamic changes in the mouse skeletal muscle proteome during denervation-induced atrophy publication-title: Dis. Model. Mech. – volume: 4 start-page: 199 year: 2006 end-page: 210 ident: bb0150 article-title: Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway publication-title: Cell Metab. – volume: 277 start-page: 653 year: 1997 end-page: 659 ident: bb0255 article-title: Iron-sulfur clusters: nature’s modular, multipurpose structures publication-title: Science – volume: 440 start-page: 137 year: 2011 end-page: 146 ident: bb0250 article-title: Rim2, a pyrimidine nucleotide exchanger, is needed for iron utilization in mitochondria publication-title: Biochem. J. – volume: 23 start-page: 2852 year: 2018 end-page: 2863 ident: bb0190 article-title: Ubiquitin-dependent degradation of mitochondrial proteins regulates energy metabolism publication-title: Cell Rep. – volume: 1 start-page: 418 year: 2006 end-page: 428 ident: bb0340 article-title: Blue native PAGE publication-title: Nat. Protoc. – volume: 15 year: 2020 ident: bb0185 article-title: Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1 publication-title: PLoS One – volume: 426 start-page: 908 year: 2014 end-page: 920 ident: bb0320 article-title: C1orf163/RESA1 is a novel mitochondrial intermembrane space protein connected to respiratory chain assembly publication-title: J. Mol. Biol. – volume: 23 start-page: 88 year: 2019 end-page: 97 ident: bb0125 article-title: Perm1 regulates CaMKII activation and shapes skeletal muscle responses to endurance exercise training publication-title: Mol Metab – volume: 2 start-page: 1896 year: 2007 end-page: 1906 ident: bb0275 article-title: Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips publication-title: Nat. Protoc. – volume: 547 start-page: 179 year: 2017 end-page: 184 ident: bb0065 article-title: The extracellular matrix protein agrin promotes heart regeneration in mice publication-title: Nature – volume: 20 start-page: 267 year: 2014 end-page: 279 ident: bb0220 article-title: Lipin-1 regulates autophagy clearance and intersects with statin drug effects in skeletal muscle publication-title: Cell Metab. – volume: 23 start-page: 113 year: 2015 end-page: 122 ident: bb0210 article-title: Rhabdomyolysis-associated mutations in human LPIN1 Lead to loss of phosphatidic acid Phosphohydrolase activity publication-title: JIMD Rep – volume: 26 start-page: 1367 year: 2008 end-page: 1372 ident: bb0285 article-title: MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification publication-title: Nat. Biotechnol. – volume: 12 start-page: 392 year: 2006 end-page: 398 ident: bb0225 article-title: Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase publication-title: J. Card. Fail. – volume: 288 start-page: 25207 year: 2013 end-page: 25218 ident: bb0050 article-title: PGC-1 and ERR-induced Regulator in Muscle 1 (PERM1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells publication-title: J. Biol. Chem. – volume: 14 year: 2019 ident: bb0130 article-title: Acute sprint exercise transcriptome in human skeletal muscle publication-title: PLoS One – volume: 6 start-page: 359 year: 2009 end-page: 362 ident: bb0280 article-title: Universal sample preparation method for proteome analysis publication-title: Nat. Methods – volume: 30 start-page: 674 year: 2016 end-page: 687 ident: bb0115 article-title: Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle publication-title: FASEB J. – volume: 62 start-page: 436 year: 1999 end-page: 444 ident: bb0205 article-title: Genetic, physical, and transcript map of the fld region on mouse chromosome 12 publication-title: Genomics – volume: 104 start-page: 5318 year: 2007 end-page: 5323 ident: bb0260 article-title: MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 588 start-page: 2443 year: 2010 end-page: 2454 ident: bb0175 article-title: Postnatal development of mouse heart: formation of energetic microdomains publication-title: J. Physiol. – volume: 56 start-page: 130 year: 2010 end-page: 140 ident: bb0035 article-title: Energy metabolic phenotype of the cardiomyocyte during development, differentiation, and postnatal maturation publication-title: J. Cardiovasc. Pharmacol. – volume: 44 start-page: 1 year: 2019 end-page: 8 ident: bb0135 article-title: Endurance training alters YKL40, PERM1, and HSP70 skeletal muscle protein contents in men with type 2 diabetes mellitus publication-title: Endocr. Res. – volume: 45 start-page: 244 year: 2020 end-page: 258 ident: bb0240 article-title: The SLC25 mitochondrial carrier family: structure and mechanism publication-title: Trends Biochem. Sci. – volume: 1446 start-page: 78 year: 2016 end-page: 90 ident: bb0355 article-title: Benzoyl chloride derivatization with liquid chromatography-mass spectrometry for targeted metabolomics of neurochemicals in biological samples publication-title: J. Chromatogr. A – volume: 41 start-page: 1067 year: 2000 end-page: 1076 ident: bb0140 article-title: Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene publication-title: J. Lipid Res. – volume: 289 start-page: 13374 year: 2014 end-page: 13384 ident: bb0160 article-title: The human gene SLC25A29, of solute carrier family 25, encodes a mitochondrial transporter of basic amino acids publication-title: J. Biol. Chem. – volume: 9 start-page: 4230 year: 2018 ident: bb0105 article-title: Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions publication-title: Nat. Commun. – volume: 51 start-page: 120 year: 2011 end-page: 128 ident: bb0145 article-title: Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor gamma coactivator 1alpha/estrogen related receptor axis publication-title: J. Mol. Cell. Cardiol. – volume: 56 start-page: 2029 year: 2015 end-page: 2039 ident: bb0360 article-title: An LC-MS/MS method to quantify acylcarnitine species including isomeric and odd-numbered forms in plasma and tissues publication-title: J. Lipid Res. – volume: 525 start-page: 479 year: 2015 end-page: 485 ident: bb0180 article-title: Epicardial FSTL1 reconstitution regenerates the adult mammalian heart publication-title: Nature – volume: 21 start-page: 353 year: 2015 end-page: 362 ident: bb0325 article-title: Myocardial healing requires Reg3 [beta]-dependent accumulation of macrophages in the ischemic heart publication-title: Nat. Med. – volume: 83 start-page: 489 year: 2008 end-page: 494 ident: bb0215 article-title: Mutations in LPIN1 cause recurrent acute myoglobinuria in childhood publication-title: Am. J. Hum. Genet. – volume: 8 start-page: 12648 year: 2018 ident: bb0300 article-title: Instant clue: a software suite for interactive data visualization and analysis publication-title: Sci. Rep. – volume: 23 start-page: 2852 issue: 10 year: 2018 ident: 10.1016/j.yjmcc.2021.01.010_bb0190 article-title: Ubiquitin-dependent degradation of mitochondrial proteins regulates energy metabolism publication-title: Cell Rep. doi: 10.1016/j.celrep.2018.05.013 – volume: 18 start-page: 2991 issue: 11 year: 1999 ident: 10.1016/j.yjmcc.2021.01.010_bb0305 article-title: Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein publication-title: EMBO J. doi: 10.1093/emboj/18.11.2991 – volume: 7 issue: 4 year: 2017 ident: 10.1016/j.yjmcc.2021.01.010_bb0195 article-title: Control of mitochondrial biogenesis and function by the ubiquitin-proteasome system publication-title: Open Biol. doi: 10.1098/rsob.170007 – volume: 5 start-page: 5491 year: 2014 ident: 10.1016/j.yjmcc.2021.01.010_bb0245 article-title: Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers publication-title: Nat. Commun. doi: 10.1038/ncomms6491 – volume: 19 issue: 5 year: 2018 ident: 10.1016/j.yjmcc.2021.01.010_bb0335 article-title: CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis publication-title: EMBO Rep. doi: 10.15252/embr.201745126 – volume: 89 start-page: 7667 issue: 14 year: 2017 ident: 10.1016/j.yjmcc.2021.01.010_bb0350 article-title: Anion-exchange chromatography coupled to high-resolution mass spectrometry: a powerful tool for merging targeted and non-targeted metabolomics publication-title: Anal. Chem. doi: 10.1021/acs.analchem.7b01624 – volume: 10 start-page: 3474 issue: 8 year: 2011 ident: 10.1016/j.yjmcc.2021.01.010_bb0020 article-title: Comparison of ERLIC-TiO2, HILIC-TiO2, and SCX-TiO2 for global phosphoproteomics approaches publication-title: J. Proteome Res. doi: 10.1021/pr200092z – volume: 277 start-page: 653 issue: 5326 year: 1997 ident: 10.1016/j.yjmcc.2021.01.010_bb0255 article-title: Iron-sulfur clusters: nature’s modular, multipurpose structures publication-title: Science doi: 10.1126/science.277.5326.653 – volume: 14 start-page: 543 issue: 8 year: 2015 ident: 10.1016/j.yjmcc.2021.01.010_bb0155 article-title: SLC transporters as therapeutic targets: emerging opportunities publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd4626 – volume: 4 year: 2015 ident: 10.1016/j.yjmcc.2021.01.010_bb0070 article-title: Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion publication-title: Elife doi: 10.7554/eLife.07455 – volume: 85 start-page: 513 issue: 4 year: 1996 ident: 10.1016/j.yjmcc.2021.01.010_bb0075 article-title: Agrin acts via a MuSK receptor complex publication-title: Cell doi: 10.1016/S0092-8674(00)81252-0 – volume: 22 start-page: 1948 issue: 14 year: 2008 ident: 10.1016/j.yjmcc.2021.01.010_bb0045 article-title: Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart publication-title: Genes Dev. doi: 10.1101/gad.1661708 – volume: 98 start-page: 5116 issue: 9 year: 2001 ident: 10.1016/j.yjmcc.2021.01.010_bb0295 article-title: Significance analysis of microarrays applied to the ionizing radiation response publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.091062498 – volume: 38 issue: 1 year: 2019 ident: 10.1016/j.yjmcc.2021.01.010_bb0230 article-title: Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy publication-title: EMBO J. doi: 10.15252/embj.201899576 – volume: 9 start-page: 671 issue: 7 year: 2012 ident: 10.1016/j.yjmcc.2021.01.010_bb0330 article-title: NIH image to ImageJ: 25 years of image analysis publication-title: Nat. Methods doi: 10.1038/nmeth.2089 – volume: 143 start-page: 1174 issue: 7 year: 2010 ident: 10.1016/j.yjmcc.2021.01.010_bb0010 article-title: A tissue-specific atlas of mouse protein phosphorylation and expression publication-title: Cell doi: 10.1016/j.cell.2010.12.001 – volume: 23 start-page: 88 year: 2019 ident: 10.1016/j.yjmcc.2021.01.010_bb0125 article-title: Perm1 regulates CaMKII activation and shapes skeletal muscle responses to endurance exercise training publication-title: Mol Metab doi: 10.1016/j.molmet.2019.02.009 – volume: 83 start-page: 489 issue: 4 year: 2008 ident: 10.1016/j.yjmcc.2021.01.010_bb0215 article-title: Mutations in LPIN1 cause recurrent acute myoglobinuria in childhood publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2008.09.002 – volume: 289 start-page: 13374 issue: 19 year: 2014 ident: 10.1016/j.yjmcc.2021.01.010_bb0160 article-title: The human gene SLC25A29, of solute carrier family 25, encodes a mitochondrial transporter of basic amino acids publication-title: J. Biol. Chem. doi: 10.1074/jbc.M114.547448 – volume: 211 start-page: 1057 issue: 5 year: 2015 ident: 10.1016/j.yjmcc.2021.01.010_bb0345 article-title: A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity publication-title: J. Cell Biol. doi: 10.1083/jcb.201404147 – volume: 176 start-page: 135 issue: 1–2 year: 1997 ident: 10.1016/j.yjmcc.2021.01.010_bb0015 article-title: Biological significance of phosphorylation and myristoylation in the regulation of cardiac muscle proteins publication-title: Mol. Cell. Biochem. doi: 10.1023/A:1006891302017 – volume: 2 start-page: 1896 issue: 8 year: 2007 ident: 10.1016/j.yjmcc.2021.01.010_bb0275 article-title: Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips publication-title: Nat. Protoc. doi: 10.1038/nprot.2007.261 – volume: 288 start-page: 25207 issue: 35 year: 2013 ident: 10.1016/j.yjmcc.2021.01.010_bb0200 article-title: Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.M113.489674 – volume: 10 start-page: 881 issue: 7 year: 2017 ident: 10.1016/j.yjmcc.2021.01.010_bb0110 article-title: Dynamic changes in the mouse skeletal muscle proteome during denervation-induced atrophy publication-title: Dis. Model. Mech. doi: 10.1242/dmm.028910 – volume: 116 start-page: 767 issue: 5 year: 2015 ident: 10.1016/j.yjmcc.2021.01.010_bb0080 article-title: The transcriptional landscape of regenerating newborn mouse hearts publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.115.305918 – volume: 234 start-page: 364 issue: 4774 year: 1986 ident: 10.1016/j.yjmcc.2021.01.010_bb0095 article-title: Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis publication-title: Science doi: 10.1126/science.2876518 – volume: 17 start-page: 349 issue: 3 year: 2003 ident: 10.1016/j.yjmcc.2021.01.010_bb0090 article-title: One-thousand-and-one substrates of protein kinase CK2? publication-title: FASEB J. doi: 10.1096/fj.02-0473rev – volume: 9 start-page: 1210 issue: 6 year: 2013 ident: 10.1016/j.yjmcc.2021.01.010_bb0170 article-title: Postnatal cardiomyocyte growth and mitochondrial reorganization cause multiple changes in the proteome of human cardiomyocytes publication-title: Mol. BioSyst. doi: 10.1039/c3mb25556e – volume: 440 start-page: 137 issue: 1 year: 2011 ident: 10.1016/j.yjmcc.2021.01.010_bb0250 article-title: Rim2, a pyrimidine nucleotide exchanger, is needed for iron utilization in mitochondria publication-title: Biochem. J. doi: 10.1042/BJ20111036 – volume: 56 start-page: 2029 issue: 10 year: 2015 ident: 10.1016/j.yjmcc.2021.01.010_bb0360 article-title: An LC-MS/MS method to quantify acylcarnitine species including isomeric and odd-numbered forms in plasma and tissues publication-title: J. Lipid Res. doi: 10.1194/jlr.D061721 – volume: 284 start-page: 21446 issue: 32 year: 2009 ident: 10.1016/j.yjmcc.2021.01.010_bb0310 article-title: Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.016600 – volume: 6 issue: 278 year: 2013 ident: 10.1016/j.yjmcc.2021.01.010_bb0030 article-title: In vivo phosphoproteomics analysis reveals the cardiac targets of beta-adrenergic receptor signaling publication-title: Sci. Signal. doi: 10.1126/scisignal.2003506 – volume: 288 start-page: 25207 issue: 35 year: 2013 ident: 10.1016/j.yjmcc.2021.01.010_bb0050 article-title: PGC-1 and ERR-induced Regulator in Muscle 1 (PERM1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.M113.489674 – volume: 23 start-page: 113 year: 2015 ident: 10.1016/j.yjmcc.2021.01.010_bb0210 article-title: Rhabdomyolysis-associated mutations in human LPIN1 Lead to loss of phosphatidic acid Phosphohydrolase activity publication-title: JIMD Rep doi: 10.1007/8904_2015_440 – volume: 426 start-page: 908 issue: 4 year: 2014 ident: 10.1016/j.yjmcc.2021.01.010_bb0320 article-title: C1orf163/RESA1 is a novel mitochondrial intermembrane space protein connected to respiratory chain assembly publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2013.12.001 – volume: 20 start-page: 267 issue: 2 year: 2014 ident: 10.1016/j.yjmcc.2021.01.010_bb0220 article-title: Lipin-1 regulates autophagy clearance and intersects with statin drug effects in skeletal muscle publication-title: Cell Metab. doi: 10.1016/j.cmet.2014.05.003 – volume: 30 start-page: 674 issue: 2 year: 2016 ident: 10.1016/j.yjmcc.2021.01.010_bb0115 article-title: Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle publication-title: FASEB J. doi: 10.1096/fj.15-276360 – volume: 146 start-page: 408 issue: 3 year: 2011 ident: 10.1016/j.yjmcc.2021.01.010_bb0235 article-title: mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway publication-title: Cell doi: 10.1016/j.cell.2011.06.034 – volume: 21 start-page: 353 issue: 4 year: 2015 ident: 10.1016/j.yjmcc.2021.01.010_bb0325 article-title: Myocardial healing requires Reg3 [beta]-dependent accumulation of macrophages in the ischemic heart publication-title: Nat. Med. doi: 10.1038/nm.3816 – volume: 4 start-page: 199 issue: 3 year: 2006 ident: 10.1016/j.yjmcc.2021.01.010_bb0150 article-title: Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway publication-title: Cell Metab. doi: 10.1016/j.cmet.2006.08.005 – volume: 1 start-page: 2856 issue: 6 year: 2006 ident: 10.1016/j.yjmcc.2021.01.010_bb0270 article-title: In-gel digestion for mass spectrometric characterization of proteins and proteomes publication-title: Nat. Protoc. doi: 10.1038/nprot.2006.468 – volume: 157 start-page: 565 issue: 3 year: 2014 ident: 10.1016/j.yjmcc.2021.01.010_bb0005 article-title: The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response publication-title: Cell doi: 10.1016/j.cell.2014.03.032 – volume: 56 start-page: 130 issue: 2 year: 2010 ident: 10.1016/j.yjmcc.2021.01.010_bb0035 article-title: Energy metabolic phenotype of the cardiomyocyte during development, differentiation, and postnatal maturation publication-title: J. Cardiovasc. Pharmacol. doi: 10.1097/FJC.0b013e3181e74a14 – volume: 286 start-page: 2240 issue: 12 year: 2019 ident: 10.1016/j.yjmcc.2021.01.010_bb0055 article-title: Posttranslational modifications of titin from cardiac muscle: how, where, and what for? publication-title: FEBS J. doi: 10.1111/febs.14854 – volume: 274 start-page: 22184 issue: 32 year: 1999 ident: 10.1016/j.yjmcc.2021.01.010_bb0165 article-title: Identification of the yeast mitochondrial transporter for oxaloacetate and sulfate publication-title: J. Biol. Chem. doi: 10.1074/jbc.274.32.22184 – volume: 15 issue: 6 year: 2020 ident: 10.1016/j.yjmcc.2021.01.010_bb0185 article-title: Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1 publication-title: PLoS One doi: 10.1371/journal.pone.0234913 – volume: 2 start-page: 419 issue: 2 year: 2012 ident: 10.1016/j.yjmcc.2021.01.010_bb0025 article-title: Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns publication-title: Cell Rep. doi: 10.1016/j.celrep.2012.07.006 – volume: 62 start-page: 436 issue: 3 year: 1999 ident: 10.1016/j.yjmcc.2021.01.010_bb0205 article-title: Genetic, physical, and transcript map of the fld region on mouse chromosome 12 publication-title: Genomics doi: 10.1006/geno.1999.6023 – volume: 1 start-page: 418 issue: 1 year: 2006 ident: 10.1016/j.yjmcc.2021.01.010_bb0340 article-title: Blue native PAGE publication-title: Nat. Protoc. doi: 10.1038/nprot.2006.62 – volume: 261 start-page: H1698 issue: 6 year: 1991 ident: 10.1016/j.yjmcc.2021.01.010_bb0040 article-title: Glycolysis is predominant source of myocardial ATP production immediately after birth publication-title: Am. J. Phys. Heart Circ. Phys. – volume: 10 start-page: 1794 issue: 4 year: 2011 ident: 10.1016/j.yjmcc.2021.01.010_bb0290 article-title: Andromeda: a peptide search engine integrated into the MaxQuant environment publication-title: J. Proteome Res. doi: 10.1021/pr101065j – volume: 45 start-page: 244 issue: 3 year: 2020 ident: 10.1016/j.yjmcc.2021.01.010_bb0240 article-title: The SLC25 mitochondrial carrier family: structure and mechanism publication-title: Trends Biochem. Sci. doi: 10.1016/j.tibs.2019.11.001 – volume: 122 start-page: 119 year: 2015 ident: 10.1016/j.yjmcc.2021.01.010_bb0120 article-title: Basal and exercise induced label-free quantitative protein profiling of m. vastus lateralis in trained and untrained individuals publication-title: J. Proteome doi: 10.1016/j.jprot.2015.03.028 – volume: 547 start-page: 179 issue: 7662 year: 2017 ident: 10.1016/j.yjmcc.2021.01.010_bb0065 article-title: The extracellular matrix protein agrin promotes heart regeneration in mice publication-title: Nature doi: 10.1038/nature22978 – volume: 99 start-page: 14855 issue: 23 year: 2002 ident: 10.1016/j.yjmcc.2021.01.010_bb0060 article-title: Potentiation of serum response factor activity by a family of myocardin-related transcription factors publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.222561499 – volume: 12 start-page: 392 issue: 5 year: 2006 ident: 10.1016/j.yjmcc.2021.01.010_bb0225 article-title: Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase publication-title: J. Card. Fail. doi: 10.1016/j.cardfail.2006.03.002 – volume: 525 start-page: 479 issue: 7570 year: 2015 ident: 10.1016/j.yjmcc.2021.01.010_bb0180 article-title: Epicardial FSTL1 reconstitution regenerates the adult mammalian heart publication-title: Nature doi: 10.1038/nature15372 – volume: 134 start-page: 353 issue: 2 year: 2008 ident: 10.1016/j.yjmcc.2021.01.010_bb0265 article-title: SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function publication-title: Cell doi: 10.1016/j.cell.2008.05.033 – volume: 51 start-page: 120 issue: 1 year: 2011 ident: 10.1016/j.yjmcc.2021.01.010_bb0145 article-title: Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor gamma coactivator 1alpha/estrogen related receptor axis publication-title: J. Mol. Cell. Cardiol. doi: 10.1016/j.yjmcc.2011.04.009 – volume: 21 start-page: 267 issue: 7 year: 1996 ident: 10.1016/j.yjmcc.2021.01.010_bb0085 article-title: PEST sequences and regulation by proteolysis publication-title: Trends Biochem. Sci. doi: 10.1016/S0968-0004(96)10031-1 – volume: 104 start-page: 5318 issue: 13 year: 2007 ident: 10.1016/j.yjmcc.2021.01.010_bb0260 article-title: MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0701078104 – volume: 8 start-page: 12648 issue: 1 year: 2018 ident: 10.1016/j.yjmcc.2021.01.010_bb0300 article-title: Instant clue: a software suite for interactive data visualization and analysis publication-title: Sci. Rep. doi: 10.1038/s41598-018-31154-6 – volume: 14 issue: 10 year: 2019 ident: 10.1016/j.yjmcc.2021.01.010_bb0130 article-title: Acute sprint exercise transcriptome in human skeletal muscle publication-title: PLoS One doi: 10.1371/journal.pone.0223024 – volume: 41 start-page: 1067 issue: 7 year: 2000 ident: 10.1016/j.yjmcc.2021.01.010_bb0140 article-title: Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene publication-title: J. Lipid Res. doi: 10.1016/S0022-2275(20)32011-3 – volume: 44 start-page: 1 issue: 1–2 year: 2019 ident: 10.1016/j.yjmcc.2021.01.010_bb0135 article-title: Endurance training alters YKL40, PERM1, and HSP70 skeletal muscle protein contents in men with type 2 diabetes mellitus publication-title: Endocr. Res. doi: 10.1080/07435800.2018.1474920 – volume: 9 start-page: 4230 issue: 1 year: 2018 ident: 10.1016/j.yjmcc.2021.01.010_bb0105 article-title: Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions publication-title: Nat. Commun. doi: 10.1038/s41467-018-06519-0 – volume: 26 start-page: 1367 issue: 12 year: 2008 ident: 10.1016/j.yjmcc.2021.01.010_bb0285 article-title: MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification publication-title: Nat. Biotechnol. doi: 10.1038/nbt.1511 – volume: 93 start-page: 97 issue: 1 year: 1982 ident: 10.1016/j.yjmcc.2021.01.010_bb0315 article-title: Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum publication-title: J. Cell Biol. doi: 10.1083/jcb.93.1.97 – volume: 6 start-page: 359 issue: 5 year: 2009 ident: 10.1016/j.yjmcc.2021.01.010_bb0280 article-title: Universal sample preparation method for proteome analysis publication-title: Nat. Methods doi: 10.1038/nmeth.1322 – volume: 14 start-page: 309 issue: 2 year: 2006 ident: 10.1016/j.yjmcc.2021.01.010_bb0100 article-title: Molecular basis for phosphorylation-dependent, PEST-mediated protein turnover publication-title: Structure doi: 10.1016/j.str.2005.11.012 – volume: 588 start-page: 2443 issue: Pt 13 year: 2010 ident: 10.1016/j.yjmcc.2021.01.010_bb0175 article-title: Postnatal development of mouse heart: formation of energetic microdomains publication-title: J. Physiol. doi: 10.1113/jphysiol.2010.189670 – volume: 1446 start-page: 78 year: 2016 ident: 10.1016/j.yjmcc.2021.01.010_bb0355 article-title: Benzoyl chloride derivatization with liquid chromatography-mass spectrometry for targeted metabolomics of neurochemicals in biological samples publication-title: J. Chromatogr. A doi: 10.1016/j.chroma.2016.04.006 |
| SSID | ssj0009433 |
| Score | 2.4066477 |
| Snippet | Heart development relies on PTMs that control cardiomyocyte proliferation, differentiation and cardiac morphogenesis. We generated a map of phosphorylation... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 41 |
| SubjectTerms | Heart development Lipid metabolism Mitochondria PERM1 Phosphoproteomics SILAC |
| Title | Phosphoproteomics of the developing heart identifies PERM1 - An outer mitochondrial membrane protein |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0022282821000250 https://dx.doi.org/10.1016/j.yjmcc.2021.01.010 https://www.ncbi.nlm.nih.gov/pubmed/33549681 https://www.proquest.com/docview/2487429097 |
| Volume | 154 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR1rS9xAcLAnlH4pam17vthCP5qa3exuLh8PUa4eJyKKfluyj-BJLzl65we_-NudyeOkYC2UBEJCJo-Z2XnszgPge-C8KFTKI-djG0kvVJQL7iJRDERq8yzN6qy0ybkeXcuzW3W7BsddLgyFVbayv5HptbRurxy12DyaT6eU40uzF7jRFLUgv31dJJlWPVgf_hyPzl9q78qmozwFrhNAV3yoDvN6vJ85KmUoeF2-kzJpX1dQfzNAa0V0ugEfWwuSDZuP3IS1UG7B-0m7Rv4J_MVdtZjfVXUFBso5XrCqYGjnsZcEKUZ9rJds6ptYobBgFyeXE84iNixZRV0e2AyHOorG0hOHslmYoVtdBlY_dVpuw9XpydXxKGp7KUQOTaRlZNH1i8MgywsvBc_TRKdOC2uV9R5tOC5CkLl1PNfBqoAkUsqhNZdxp3ThffIZemVVhq_AMtSqthBOhoGTsUN3Q-lEuoCCodA22D6IDn_GtXXGqd3FL9MFlN2bGumGkG5i2uM-HK6A5k2Zjbdvlx1hTJdBijLPoBp4G0yvwP5gsn8Dfuuob3D40ZoKorx6WBiBDh-q9DhL-_ClYYvVDyQJIlAP-M7_vnYXPtBZE1-5B73l74ewjzbQ0h7Aux9P_KDldDqOL2_Gzy0bB6w |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT-MwELYQKy1cVsu77AMjcSQQO7bTHBFq1d1tEUJF4mbFj4gimlTbcuCyv31nnKRoJehKKDklnjzG9jzsb2YIOfGMFYVMWWRdbCLhuIxyzmzEiy5PTZ6lWYhKG12pwa34eSfv1shlGwuDsMpG9tcyPUjr5sp5w83z2WSCMb64egEHLlFz9Ns_CJmkiOs7-_OC88hEXU8eYevYvE09FEBezw9Ti4kMOQvJOzGO9nX19Jb5GdRQ_zP51NiP9KL-xC2y5stt8nHU7JDvEHd9X81n91XIv4ARx3NaFRSsPPoSHkWxivWCTlyNFPJzet27GTEa0YuSVljjgU5hooNgLB2OTzr1U3CqS0_DUyflLhn3e-PLQdRUUogsGEiLyIDjF_tulhdOcJaniUqt4sZI4xxYcIx7L3JjWa68kR46SEoLtlzGrFSFc8keWS-r0h8QmoFONQW3wnetiC04G1IlwnoQC4Uy3nQIb_mnbZNlHItdPOoWTvagA9M1Ml3HeMYdcrokmtVJNlY3F23H6DZ-FCSeBiWwmkwtyf4ZYv8nPG57X8Pkwx0VYHn1NNcc3D1Q6HGWdsh-PSyWP5AkwEDVZYfvfe0R2RiMR0M9_HH16wvZxDs10vIrWV_8fvLfwBpamO9htP8FMWQG1A |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Phosphoproteomics+of+the+developing+heart+identifies+PERM1+-+An+outer+mitochondrial+membrane+protein&rft.jtitle=Journal+of+molecular+and+cellular+cardiology&rft.au=Aravamudhan%2C+Sriram&rft.au=T%C3%BCrk%2C+Clara&rft.au=Bock%2C+Theresa&rft.au=Keufgens%2C+Lena&rft.date=2021-05-01&rft.issn=0022-2828&rft.volume=154&rft.spage=41&rft.epage=59&rft_id=info:doi/10.1016%2Fj.yjmcc.2021.01.010&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_yjmcc_2021_01_010 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-2828&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-2828&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-2828&client=summon |