Investigating genetic damage in workers occupationally exposed to methotrexate using three genetic end-points

• Published in: Mutagenesis Vol. 20; no. 5; pp. 351 - 357
• Main Authors: Deng, Hongping, Zhang, Meibian, He, Jiliang, Wu, Wei, Jin, Lifen, Zheng, Wei, Lou, Jianlin, Wang, Baohong
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.09.2005; Oxford Publishing Limited (England)
• Subjects: Adult; Antimetabolites, Antineoplastic - toxicity; Bioassays; Biological and medical sciences; Chromosome aberrations; Comet Assay; DNA Damage; Environmental Monitoring; Female; Fundamental and applied biological sciences. Psychology; Genetic Markers; Humans; Hypoxanthine Phosphoribosyltransferase - genetics; Male; Methotrexate - toxicity; Micronuclei, Chromosome-Defective - chemically induced; Micronucleus Tests; Middle Aged; Molecular and cellular biology; Molecular genetics; Mutagenesis. Repair; Mutation; Occupational Exposure; Sex Factors; Antineoplastic agent; Genetics; Worker; Mutagenesis; Occupational exposure; Methotrexate

Genetic damage in workers occupationally exposed to an antineoplastic drug was studied using the micronucleus (MN) test, the comet assay, the hprt gene mutation assay and the TCR gene mutation assay. The subjects were divided into two groups: (i) 21 workers from a plant producing methotrexate (MTX);...