Molecular Characterization of the Dot/Icm-Translocated AnkH and AnkJ Eukaryotic-Like Effectors of Legionella pneumophila

• Published in: Infection and Immunity Vol. 78; no. 3; pp. 1123 - 1134
• Main Authors: Habyarimana, Fabien, Price, Chris T, Santic, Marina, Al-Khodor, Souhaila, Kwaik, Yousef Abu
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.03.2010; American Society for Microbiology (ASM)
• Subjects: Animals; Ankyrins - genetics; Ankyrins - physiology; Bacteriology; Biological and medical sciences; Cell Line; Colony Count, Microbial; Cytoplasm - chemistry; Disease Models, Animal; Fundamental and applied biological sciences. Psychology; Humans; Legionella pneumophila; Legionella pneumophila - pathogenicity; Legionnaires' Disease - microbiology; Mice; Microbiology; Miscellaneous; Molecular Chaperones - genetics; Molecular Chaperones - metabolism; Molecular Pathogenesis; Protein Interaction Domains and Motifs; Protein Interaction Mapping; Survival Analysis; Virulence Factors - genetics; Virulence Factors - physiology; Bacteria; Legionella pneumophila; Legionellaceae; Immunity

Although most Dot/Icm-translocated effectors of Legionella pneumophila are not required for intracellular proliferation, the eukaryotic-like ankyrin effectors, AnkH and AnkJ are required for intracellular proliferation. In this report, we show that the IcmSW chaperones are essential for translocatio...