Phosphorylation network dynamics in the control of cell cycle transitions

• Published in: Journal of cell science Vol. 125; no. 20; pp. 4703 - 4711
• Main Authors: Fisher, Daniel, Krasinska, Liliana, Coudreuse, Damien, Novák, Béla
• Format: Journal Article
• Language: English
• Published: England Company of Biologists 15.10.2012
• Subjects: CDC2 Protein Kinase - genetics; CDC2 Protein Kinase - metabolism; Cell Cycle Checkpoints - genetics; Cyclin B - genetics; Cyclin B - metabolism; DNA Replication; Genetics; Humans; Life Sciences; Mitosis - genetics; Phosphoric Monoester Hydrolases - genetics; Phosphoric Monoester Hydrolases - metabolism; Phosphorylation; S Phase Cell Cycle Checkpoints - genetics; Saccharomyces cerevisiae - genetics; Schizosaccharomyces pombe; S Phase Cell Cycle Checkpoints; Phosphoric Monoester Hydrolases; CDC2 Protein Kinase; Phosphorylation; Cell Cycle Checkpoints; Mitosis; Cyclin B; Humans; DNA Replication; Saccharomyces cerevisiae

Fifteen years ago, it was proposed that the cell cycle in fission yeast can be driven by quantitative changes in the activity of a single protein kinase complex comprising a cyclin – namely cyclin B – and cyclin dependent kinase 1 (Cdk1). When its activity is low, Cdk1 triggers the onset of S phase;...