Diabetic retinopathy is a ceramidopathy reversible by anti-ceramide immunotherapy - Dorweiler, Tim F.; Singh, Arjun; Ganju, Aditya; Lydic, Todd A.; Glazer, Louis C.; Kolesnick, Richard N.; Busik, Julia V. (Cell metabolism, 2024)
Keywords: Animals; apoptosis; Apoptosis - drug effects; ceramide; Ceramides - metabolism; diabetes; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - pathology; diabetic retinopathy; Diabetic Retinopathy - drug therapy; Diabetic Retinopathy - immunology; Diabetic Retinopathy - metabolism; Diabetic Retinopathy - pathology; endothelial cell; Endothelial Cells - metabolism; Female; Humans; IL-1β; Immunotherapy; inflammation; Interleukin-1beta - metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Rats; retina; Retina - metabolism; Retina - pathology; sphingomyelinase; TNFα; Tumor Necrosis Factor-alpha - metabolism; Vitreous Body - metabolism; ceramide; TNFα; retina; inflammation; endothelial cell; sphingomyelinase; apoptosis; diabetic retinopathy; IL-1β; diabetes