Fractionation of a Herbal Antidiarrheal Medicine Reveals Eugenol as an Inhibitor of Ca2+-Activated Cl− Channel TMEM16A - Yao, Zhen; Namkung, Wan; Ko, Eun A.; Park, Jinhong; Tradtrantip, Lukmanee; Verkman, A. S. (PloS one, 2012)
Keywords: Analgesics - chemistry; Analgesics - pharmacology; Anoctamin-1; Antidiarrheals - chemistry; Antidiarrheals - pharmacology; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biology; Calcium; Cell growth; Cell Line; Chloride Channels - antagonists & inhibitors; Chromatography; Conductance; Cystic fibrosis; Eugenol; Eugenol - analysis; Eugenol - pharmacology; Fractionation; Herbal medicine; High-performance liquid chromatography; Humans; Inhibition; Interstitial cells; Interstitial cells of Cajal; Intestine; Liquid chromatography; Medicine; Muscle contraction; Muscles; Neoplasm Proteins - antagonists & inhibitors; Oils & fats; Pain; Pharmaceutical sciences; Pharmacy; Physiology; Plant Extracts - chemistry; Plant Extracts - pharmacology; Resistance; Rodents; Signaling; Smooth muscle; Structure-Activity Relationship; Tumors; United States--US; San Francisco California; California