Association between premature mortality and hypopituitarism

• Published in: The Lancet (British edition) Vol. 357; no. 9254; pp. 425 - 431
• Main Authors: Tomlinson, JW, Holden, N, Hills, RK, Wheatley, K, Clayton, RN, Bates, AS, Sheppard, MC, Stewart, PM
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 10.02.2001; Lancet; Elsevier Limited
• Subjects: Age; Analysis. Health state; Biological and medical sciences; Cardiovascular diseases; Cerebrovascular system; Diagnosis; Disease; Endocrinopathies; Epidemiology; Fatalities; General aspects; Gonadotropins; Growth hormones; Health risks; Hypertension; Hypopituitarism; Hypothalamus. Hypophysis. Epiphysis (diseases); Insulin; Medical disorders; Medical prognosis; Medical research; Medical sciences; Mortality; Neoplasia; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Patients; Pituitary; Pituitary (anterior); Pituitary gland; Population; Premature mortality; Public health. Hygiene; Public health. Hygiene-occupational medicine; Radiation therapy; Regression analysis; Respiratory diseases; Risk analysis; Risk factors; Sex; Surgery; Tumors; United Kingdom; Europe; United Kingdom > UK; Midlands (England); England; Endocrinopathy; Human; Hypophyseal insufficiency; Follow up study; Mortality; Pituitary diseases; Cause; Risk factor; Adult; Child; Epidemiology; Public health

Four retrospective studies have reported premature mortality in patients with hypopituitarism with standard mortality ratios (SMRs) varying between 1·20 and 2·17. Patients with hypopituitarism have complex endocrine deficiencies, and the mechanisms underpinning any excess mortality are unknown. Furt...