The Detrimental Effects of Peripartum Antibiotics on Gut Proliferation and Formula Feeding Injury in Neonatal Mice Are Alleviated with Lactobacillus rhamnosus GG

• Published in: Microorganisms (Basel) Vol. 11; no. 6; p. 1482
• Main Authors: Cuna, Alain, Nsumu, Marianne, Menden, Heather L, Chavez-Bueno, Susana, Sampath, Venkatesh
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.06.2023; MDPI
• Subjects: Antibiotics; Antigens; Apoptosis; Cell activation; Cytokines; Dietary supplements; Digestive system; Enterocolitis; Experiments; Exposure; Gastrointestinal tract; Gene expression; gut microbiome; Initiatives; Injury prevention; Intestinal microflora; Intestine; Juveniles; Kinases; Lactobacilli; Lactobacillus rhamnosus; Microbiomes; Necrotizing enterocolitis; Neonates; Newborn babies; Olfactomedin; Permeability; postnatal gut adaptation; Premature babies; Probiotics; Proliferating cell nuclear antigen; Proteins; Risk; Sepsis; Small intestine; Villus; Wnt protein; United States > US; necrotizing enterocolitis; gut microbiome; antibiotics; postnatal gut adaptation; probiotics

Peripartum antibiotics can negatively impact the developing gut microbiome and are associated with necrotizing enterocolitis (NEC). The mechanisms by which peripartum antibiotics increase the risk of NEC and strategies that can help mitigate this risk remain poorly understood. In this study, we dete...