Elevated ATP via enhanced miRNA-30b, 30c, and 30e downregulates the expression of CD73 in CD8+ T cells of HIV-infected individuals

• Published in: PLoS pathogens Vol. 18; no. 3; p. e1010378
• Main Authors: Shahbaz, Shima, Okoye, Isobel, Blevins, Gregg, Elahi, Shokrollah
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.03.2022; Public Library of Science (PLoS)
• Subjects: 5'-Nucleotidase - genetics; Adenosine; Adenosine Triphosphate - metabolism; Antigens; Antiretroviral agents; Antiretroviral drugs; Antiretroviral therapy; ATP; Binding sites; Biology and Life Sciences; CC chemokine receptors; CCR7 protein; CD73 antigen; CD8 antigen; CD8-Positive T-Lymphocytes - metabolism; Cell migration; Cell surface; Central nervous system; Cerebrospinal fluid; Cytokines; Flow cytometry; Gene expression; GPI-Linked Proteins - genetics; HIV; HIV Infections - metabolism; Homing behavior; Homing receptors; Human immunodeficiency virus; Human subjects; Humans; Hypoxia; Infections; Inflammation; Interleukin 2; Lymphocytes; Lymphocytes T; Medicine and Health Sciences; Memory cells; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; mRNA; Multiple sclerosis; Peripheral blood; Proteins; Receptors; Research and Analysis Methods; Risk management; Risk reduction; Statistical analysis; T-Lymphocyte Subsets; Tumor necrosis factor-α; γ-Interferon

CD8 + T cells play a crucial role against chronic viral infections, however, their effector functions are influenced by the expression of co-stimulatory/inhibitory receptors. For example, CD73 works with CD39 to convert highly inflammatory ATP to adenosine. However, its expression on T cells in the...