Gut microbiome lipid metabolism and its impact on host physiology

• Published in: Cell host & microbe Vol. 31; no. 2; pp. 173 - 186
• Main Authors: Brown, Eric M., Clardy, Jon, Xavier, Ramnik J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 08.02.2023
• Subjects: Animals; autoimmune disease; bacteria; cholesterol; diet; Gastrointestinal Microbiome - physiology; Immune System; inflammation; innate immunity; Lipid Metabolism; Lipids; Mammals; metabolism; microbiome; phospholipids; PUFAs; sphingolipids; lipids; bacteria; innate immunity; inflammation; sphingolipids; cholesterol; metabolism; diet; phospholipids; PUFAs; microbiome; autoimmune disease

Metabolites produced by commensal gut microbes impact host health through their recognition by the immune system and their influence on numerous metabolic pathways. Notably, the gut microbiota can both transform and synthesize lipids as well as break down dietary lipids to generate secondary metabol...