Repetitive Traumatic Brain Injury Is Associated With TDP-43 Alterations, Neurodegeneration, and Glial Activation in Mice

• Published in: Journal of neuropathology and experimental neurology Vol. 80; no. 1; pp. 2 - 14
• Main Authors: Rajič Bumber, Jelena, Pilipović, Kristina, Janković, Tamara, Dolenec, Petra, Gržeta, Nika, Križ, Jasna, Župan, Gordana
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.01.2021
• Subjects: Brain; Degeneration; Genetic aspects; Health aspects; Injuries; Nervous system; Neurodegeneration; Neuroglia; Proteins; Ribonucleoproteins; Traumatic brain injury; Croatia; Mouse; TDP-43 protein; Neuroglia; Nerve degeneration; Brain concussion

Increasing evidence points to a relationship between repetitive mild traumatic brain injury (mTBI), the Tar DNA binding protein 43 (TDP-43) pathology and some neurodegenerative diseases, but the underlying pathophysiological mechanisms are still unknown. We examined TDP-43 regulation, neurodegenerat...