Functional Genetic Variants in the 3′-Untranslated Region of Sulfotransferase Isoform 1A1 (SULT1A1) and Their Effect on Enzymatic Activity

• Published in: Toxicological sciences Vol. 118; no. 2; pp. 391 - 403
• Main Authors: Yu, Xinfeng, Dhakal, Ishwori B., Beggs, Marjorie, Edavana, Vineetha Koroth, Williams, Suzanne, Zhang, Xuemei, Mercer, Kelly, Ning, Baitang, Lang, Nicholas P., Kadlubar, Fred F., Kadlubar, Susan
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.12.2010
• Subjects: 3' Untranslated Regions - genetics; Adult; Aged; Aged, 80 and over; Arylsulfotransferase - genetics; Arylsulfotransferase - metabolism; Biotransformation and Toxicokinetics; Blood Platelets - enzymology; Cytosol - enzymology; Enzyme Activation - genetics; Female; Gene Expression Regulation, Enzymologic; Genotype; Humans; Linkage Disequilibrium; Liver - enzymology; Male; MicroRNAs - genetics; Middle Aged; pharmacogenetics; phenotype; Polymorphism, Single Nucleotide - genetics; SULT1A1

Sulfotransferase isoform 1A1 (SULT1A1) is the most highly expressed hepatic sulfotransferase and is involved in the biotransformation of a wide variety of endo- and xenobiotics. A common single nucleotide polymorphism (SNP) in the coding region of SULT1A1, several proximal promoter SNPs, and copy nu...