Update on the applications and limitations of alpha-fetoprotein for hepatocellular carcinoma

• Published in: World journal of gastroenterology : WJG Vol. 28; no. 2; pp. 216 - 229
• Main Authors: Hanif, Hira, Ali, Mukarram Jamat, Susheela, Ammu T, Khan, Iman Waheed, Luna-Cuadros, Maria Alejandra, Khan, Muzammil Muhammad, Lau, Daryl Tan-Yeung
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 14.01.2022
• Subjects: alpha-Fetoproteins; Biomarkers, Tumor - genetics; Carcinoma, Hepatocellular - diagnostic imaging; Humans; Liver Cirrhosis; Liver Neoplasms - diagnostic imaging; Minireviews; Cirrhosis; Hepatocellular carcinoma; Alpha-fetoprotein-L3; Tumor markers; Hereditary persistence of alpha-fetoprotein; Alpha-fetoprotein

Alpha-fetoprotein (AFP) is an oncofetal glycoprotein that has been used as a tumor marker for hepatocellular carcinoma (HCC) in combination with ultrasound and other imaging modalities. Its utility is limited because of both low sensitivity and specificity, and discrepancies among the different meth...