Update on the applications and limitations of alpha-fetoprotein for hepatocellular carcinoma

Alpha-fetoprotein (AFP) is an oncofetal glycoprotein that has been used as a tumor marker for hepatocellular carcinoma (HCC) in combination with ultrasound and other imaging modalities. Its utility is limited because of both low sensitivity and specificity, and discrepancies among the different meth...

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Published inWorld journal of gastroenterology : WJG Vol. 28; no. 2; pp. 216 - 229
Main Authors Hanif, Hira, Ali, Mukarram Jamat, Susheela, Ammu T, Khan, Iman Waheed, Luna-Cuadros, Maria Alejandra, Khan, Muzammil Muhammad, Lau, Daryl Tan-Yeung
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 14.01.2022
Subjects
alpha-Fetoproteins
Biomarkers, Tumor - genetics
Carcinoma, Hepatocellular - diagnostic imaging
Humans
Liver Cirrhosis
Liver Neoplasms - diagnostic imaging
Minireviews
Cirrhosis
Hepatocellular carcinoma
Alpha-fetoprotein-L3
Tumor markers
Hereditary persistence of alpha-fetoprotein
Alpha-fetoprotein
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Abstract Alpha-fetoprotein (AFP) is an oncofetal glycoprotein that has been used as a tumor marker for hepatocellular carcinoma (HCC) in combination with ultrasound and other imaging modalities. Its utility is limited because of both low sensitivity and specificity, and discrepancies among the different methods of measurements. Moreover, its accuracy varies according to patient characteristics and the AFP cut-off values used. Combination of AFP with novel biomarkers such as AFP-L3, Golgi specific membrane protein (GP73) and des-gamma-carboxyprothrombin significantly improved its accuracy in detecting HCC. Increased AFP level could also signify severity of hepatic destruction and subsequent regeneration and is commonly observed in patients with acute and chronic liver conditions and cirrhosis. Hereditary and other non-hepatic disorders can also cause AFP elevation.
AbstractList Alpha-fetoprotein (AFP) is an oncofetal glycoprotein that has been used as a tumor marker for hepatocellular carcinoma (HCC) in combination with ultrasound and other imaging modalities. Its utility is limited because of both low sensitivity and specificity, and discrepancies among the different methods of measurements. Moreover, its accuracy varies according to patient characteristics and the AFP cut-off values used. Combination of AFP with novel biomarkers such as AFP-L3, Golgi specific membrane protein (GP73) and des-gamma-carboxyprothrombin significantly improved its accuracy in detecting HCC. Increased AFP level could also signify severity of hepatic destruction and subsequent regeneration and is commonly observed in patients with acute and chronic liver conditions and cirrhosis. Hereditary and other non-hepatic disorders can also cause AFP elevation.Alpha-fetoprotein (AFP) is an oncofetal glycoprotein that has been used as a tumor marker for hepatocellular carcinoma (HCC) in combination with ultrasound and other imaging modalities. Its utility is limited because of both low sensitivity and specificity, and discrepancies among the different methods of measurements. Moreover, its accuracy varies according to patient characteristics and the AFP cut-off values used. Combination of AFP with novel biomarkers such as AFP-L3, Golgi specific membrane protein (GP73) and des-gamma-carboxyprothrombin significantly improved its accuracy in detecting HCC. Increased AFP level could also signify severity of hepatic destruction and subsequent regeneration and is commonly observed in patients with acute and chronic liver conditions and cirrhosis. Hereditary and other non-hepatic disorders can also cause AFP elevation.
Alpha-fetoprotein (AFP) is an oncofetal glycoprotein that has been used as a tumor marker for hepatocellular carcinoma (HCC) in combination with ultrasound and other imaging modalities. Its utility is limited because of both low sensitivity and specificity, and discrepancies among the different methods of measurements. Moreover, its accuracy varies according to patient characteristics and the AFP cut-off values used. Combination of AFP with novel biomarkers such as AFP-L3, Golgi specific membrane protein (GP73) and des-gamma-carboxyprothrombin significantly improved its accuracy in detecting HCC. Increased AFP level could also signify severity of hepatic destruction and subsequent regeneration and is commonly observed in patients with acute and chronic liver conditions and cirrhosis. Hereditary and other non-hepatic disorders can also cause AFP elevation.
Author Khan, Muzammil Muhammad
Khan, Iman Waheed
Hanif, Hira
Lau, Daryl Tan-Yeung
Susheela, Ammu T
Ali, Mukarram Jamat
Luna-Cuadros, Maria Alejandra
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  surname: Khan
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  givenname: Maria Alejandra
  surname: Luna-Cuadros
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  surname: Khan
  fullname: Khan, Muzammil Muhammad
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  givenname: Daryl Tan-Yeung
  surname: Lau
  fullname: Lau, Daryl Tan-Yeung
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Cites_doi 10.1001/archpedi.1979.02130050095020
10.1515/CCLM.2007.262
10.1016/j.cgh.2006.12.005
10.1016/j.cgh.2019.11.012
10.1111/j.1600-0676.1986.tb00279.x
10.1136/adc.2011.213181
10.1016/j.cca.2016.10.006
10.1007/s12253-019-00585-5
10.1186/1471-230X-14-145
10.3310/hta11340
10.1007/s13277-013-0904-y
10.1097/MD.0000000000005844
10.1016/j.jhep.2014.08.033
10.1016/j.ajg.2012.06.004
10.1016/S1470-2045(12)70233-4
10.1023/a:1008243311122
10.1080/088800101750059828
10.1111/j.1749-6632.1975.tb25398.x
10.1007/s12072-009-9156-8
10.25122/jml-2019-0076
10.1002/cld.761
10.1080/17474124.2021.1900731
10.1097/00007890-196301020-00004
10.1016/j.cld.2020.04.002
10.1046/j.1440-1746.2001.02643.x
10.1097/MD.0000000000004436
10.1111/hepr.12544
10.3748/wjg.v12.i8.1175
10.1002/hep.1840120625
10.3748/wjg.15.5976
10.1093/clinchem/37.9.1639
10.1373/clinchem.2003.024232
10.1016/0016-5085(90)91034-4
10.4103/bmfj.bmfj_33_18
10.1001/jamaoncol.2020.4930
10.1097/MPH.0b013e3182441256
10.1016/j.cld.2015.01.005
10.1002/pbc.21816
10.14309/ajg.0000000000000715
10.1016/j.jhep.2019.08.025
10.1093/gastro/goaa052
10.1155/2018/9049252
10.1097/00000441-199203000-00004
10.1136/gut.14.12.939
10.1002/1878-0261.12745
10.3390/diagnostics10080579
10.1111/j.1572-0241.1998.00703.x
10.12816/0031219
10.1038/260804a0
10.3109/10408368109105870
10.1007/s12072-017-9799-9
10.3390/ijms20225613
10.1002/1097-0142(19891015)64:8<1700::aid-cncr2820640824>3.0.co;2-z
10.1038/291201a0
10.1093/hmg/2.4.379
10.1111/j.1572-0241.2000.02091.x
10.3390/jcm9123843
10.1016/j.jhep.2005.03.019
10.1155/2014/875140
10.1159/000217540
10.7754/Clin.Lab.2018.180607
10.1097/MEG.0000000000001400
10.1001/jama.233.1.38
10.1111/j.1600-0676.1984.tb00942.x
10.21614/sgo-24-1-37
10.1186/1471-2407-7-28
10.1159/000367735
10.1002/jmv.24032
10.1016/j.sjbs.2021.06.020
10.5009/gnl16069
10.1016/0016-5085(90)90037-2
10.1186/s12885-017-3609-6
10.1097/00004836-200103000-00014
10.3109/00365521.2015.1082190
10.1002/hep.29913
10.1159/000339016
10.1001/jamasurg.2016.3310
10.4172/clinical-practice.1000393
10.7326/0003-4819-139-1-200307010-00012
10.1016/j.ejca.2010.02.005
10.1111/j.1440-1746.2007.04898.x
10.3350/cmh.2020.0032
10.1155/2020/5087643
10.1373/clinchem.2004.034157
10.1053/j.seminoncol.2012.05.001
10.1002/hep.1840090119
10.1016/j.cgh.2008.08.041
10.1186/s12876-020-01345-5
10.1053/j.gastro.2018.01.064
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Keywords Cirrhosis
Hepatocellular carcinoma
Alpha-fetoprotein-L3
Tumor markers
Hereditary persistence of alpha-fetoprotein
Alpha-fetoprotein
Language English
License The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
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Author contributions: Hanif H and Ali MJ contributed equally; Lau DTY provided the concept and direction of the review, the learning points and the editing of the manuscript; Khan MM, Hanif H, Ali MJ, Susheela AT, and Luna-Cuadros MA reviewed the literature and wrote the first manuscript draft; Khan IW and Ali MJ contributed to the addition of literature, revision and edition of the final manuscript; Khan MM and Lau DTY are joint senior authors.
Corresponding author: Daryl Tan-Yeung Lau, MD, MSc, Associate Professor, Liver Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis St. Liver Research Center, Suite 4A, Boston, MA 02215, United States. dlau@bidmc.harvard.edu
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  doi: 10.1001/archpedi.1979.02130050095020
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  doi: 10.1515/CCLM.2007.262
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  doi: 10.1016/j.cgh.2019.11.012
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  doi: 10.1111/j.1600-0676.1986.tb00279.x
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  doi: 10.1136/adc.2011.213181
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  doi: 10.1016/j.cca.2016.10.006
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  doi: 10.1007/s12253-019-00585-5
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  doi: 10.1186/1471-230X-14-145
– ident: B5
  doi: 10.3310/hta11340
– ident: B9
  doi: 10.1007/s13277-013-0904-y
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  doi: 10.1097/MD.0000000000005844
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  doi: 10.1016/j.jhep.2014.08.033
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– ident: B81
  doi: 10.1016/j.ajg.2012.06.004
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  doi: 10.1016/S1470-2045(12)70233-4
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  doi: 10.1023/a:1008243311122
– ident: B96
– ident: B15
  doi: 10.1080/088800101750059828
– ident: B3
  doi: 10.1111/j.1749-6632.1975.tb25398.x
– ident: B78
  doi: 10.1007/s12072-009-9156-8
– ident: B84
  doi: 10.25122/jml-2019-0076
– ident: B76
  doi: 10.1002/cld.761
– ident: B47
  doi: 10.1080/17474124.2021.1900731
– ident: B58
– ident: B21
  doi: 10.1097/00007890-196301020-00004
– ident: B66
  doi: 10.1016/j.cld.2020.04.002
– ident: B40
  doi: 10.1046/j.1440-1746.2001.02643.x
– ident: B49
  doi: 10.1097/MD.0000000000004436
– ident: B45
  doi: 10.1111/hepr.12544
– ident: B46
  doi: 10.3748/wjg.v12.i8.1175
– ident: B51
  doi: 10.1002/hep.1840120625
– ident: B14
  doi: 10.3748/wjg.15.5976
– ident: B2
– ident: B19
  doi: 10.1093/clinchem/37.9.1639
– ident: B93
  doi: 10.1373/clinchem.2003.024232
– ident: B32
  doi: 10.1016/0016-5085(90)91034-4
– ident: B37
  doi: 10.4103/bmfj.bmfj_33_18
– ident: B27
  doi: 10.1001/jamaoncol.2020.4930
– ident: B94
  doi: 10.1097/MPH.0b013e3182441256
– ident: B50
  doi: 10.1016/j.cld.2015.01.005
– ident: B88
  doi: 10.1002/pbc.21816
– ident: B86
  doi: 10.14309/ajg.0000000000000715
– ident: B75
  doi: 10.1016/j.jhep.2019.08.025
– ident: B20
  doi: 10.1093/gastro/goaa052
– ident: B17
  doi: 10.1155/2018/9049252
– ident: B4
  doi: 10.1097/00000441-199203000-00004
– ident: B56
  doi: 10.1136/gut.14.12.939
– ident: B48
  doi: 10.1002/1878-0261.12745
– ident: B77
  doi: 10.3390/diagnostics10080579
– ident: B82
  doi: 10.1111/j.1572-0241.1998.00703.x
– ident: B34
  doi: 10.12816/0031219
– ident: B10
  doi: 10.1038/260804a0
– ident: B11
  doi: 10.3109/10408368109105870
– ident: B7
  doi: 10.1007/s12072-017-9799-9
– ident: B74
  doi: 10.3390/ijms20225613
– ident: B1
– ident: B29
  doi: 10.1002/1097-0142(19891015)64:8<1700::aid-cncr2820640824>3.0.co;2-z
– ident: B62
– ident: B18
  doi: 10.1038/291201a0
– ident: B95
  doi: 10.1093/hmg/2.4.379
– ident: B23
  doi: 10.1111/j.1572-0241.2000.02091.x
– ident: B87
  doi: 10.3390/jcm9123843
– ident: B71
  doi: 10.1016/j.jhep.2005.03.019
– ident: B73
  doi: 10.1155/2014/875140
– ident: B28
  doi: 10.1159/000217540
– ident: B70
  doi: 10.7754/Clin.Lab.2018.180607
– ident: B72
  doi: 10.1097/MEG.0000000000001400
– ident: B13
  doi: 10.1001/jama.233.1.38
– ident: B60
  doi: 10.1111/j.1600-0676.1984.tb00942.x
– ident: B38
  doi: 10.21614/sgo-24-1-37
– ident: B80
  doi: 10.1186/1471-2407-7-28
– ident: B41
  doi: 10.1159/000367735
– ident: B59
  doi: 10.1002/jmv.24032
– ident: B39
  doi: 10.1016/j.sjbs.2021.06.020
– ident: B89
  doi: 10.5009/gnl16069
– ident: B91
  doi: 10.1016/0016-5085(90)90037-2
– ident: B42
  doi: 10.1186/s12885-017-3609-6
– ident: B68
  doi: 10.1097/00004836-200103000-00014
– ident: B44
  doi: 10.3109/00365521.2015.1082190
– ident: B6
  doi: 10.1002/hep.29913
– ident: B8
  doi: 10.1159/000339016
– ident: B30
  doi: 10.1001/jamasurg.2016.3310
– ident: B31
  doi: 10.4172/clinical-practice.1000393
– ident: B22
  doi: 10.7326/0003-4819-139-1-200307010-00012
– ident: B33
  doi: 10.1016/j.ejca.2010.02.005
– ident: B69
  doi: 10.1111/j.1440-1746.2007.04898.x
– ident: B65
  doi: 10.3350/cmh.2020.0032
– ident: B43
  doi: 10.1155/2020/5087643
– ident: B92
  doi: 10.1373/clinchem.2004.034157
– ident: B25
  doi: 10.1053/j.seminoncol.2012.05.001
– ident: B52
  doi: 10.1002/hep.1840090119
– ident: B36
  doi: 10.1016/j.cgh.2008.08.041
– ident: B57
– ident: B63
  doi: 10.1186/s12876-020-01345-5
– ident: B85
  doi: 10.1053/j.gastro.2018.01.064
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Snippet Alpha-fetoprotein (AFP) is an oncofetal glycoprotein that has been used as a tumor marker for hepatocellular carcinoma (HCC) in combination with ultrasound and...
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SubjectTerms alpha-Fetoproteins
Biomarkers, Tumor - genetics
Carcinoma, Hepatocellular - diagnostic imaging
Humans
Liver Cirrhosis
Liver Neoplasms - diagnostic imaging
Minireviews
Title Update on the applications and limitations of alpha-fetoprotein for hepatocellular carcinoma
URI https://www.ncbi.nlm.nih.gov/pubmed/35110946
https://www.proquest.com/docview/2625261058
https://pubmed.ncbi.nlm.nih.gov/PMC8776528
Volume 28
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