Antifibrotic action of pirfenidone and prednisolone: Different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis

• Published in: European journal of pharmacology Vol. 590; no. 1; pp. 400 - 408
• Main Authors: Oku, Hisashi, Shimizu, Toshikatsu, Kawabata, Tomoji, Nagira, Morio, Hikita, Ichiro, Ueyama, Azumi, Matsushima, Shuuichi, Torii, Mikinori, Arimura, Akinori
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 20.08.2008; Elsevier
• Subjects: Animals; Basic fibroblast growth factor; Biological and medical sciences; Bleomycin - toxicity; Chemokines - biosynthesis; Cytokines - biosynthesis; Dose-Response Relationship, Drug; Fibroblast Growth Factor 2 - biosynthesis; Intercellular Signaling Peptides and Proteins - biosynthesis; Interferon-gamma - biosynthesis; Interferon-γ; Interleukin-12 Subunit p40 - biosynthesis; Lung - metabolism; Male; Medical sciences; Mice; Mice, Inbred ICR; Pharmacology. Drug treatments; Pirfenidone; Pneumology; Prednisolone; Prednisolone - pharmacology; Prednisolone - therapeutic use; Pulmonary fibrosis; Pulmonary Fibrosis - chemically induced; Pulmonary Fibrosis - drug therapy; Pyridones - pharmacology; Pyridones - therapeutic use; Respiratory system : syndromes and miscellaneous diseases; Transforming Growth Factor beta1 - biosynthesis; Transforming growth factor-β1; Tumor Necrosis Factor-alpha - biosynthesis; Basic fibroblast growth factor; Pulmonary fibrosis; Transforming growth factor-β1; Pirfenidone; Interferon-γ; Prednisolone; Antineoplastic agent; Peptides; Lung; Respiratory system; Antifibrotic agent; Bleomycin; Glycopeptide; Corticosteroid; Lung disease; Respiratory disease; Rodentia; Antiinflammatory agent; Cytokine; Vertebrata; Antibiotic; Mammalia; Mouse; Animal; Adrenal hormone; Transforming growth factor β1; Immunosuppressive agent; Growth factor; Gamma interferon

Pirfenidone, a broad-spectrum antifibrotic agent, is known to have efficacy in certain fibrotic disease models, and is under clinical trials in patients with idiopathic pulmonary fibrosis. We investigated the antifibrotic effect of pirfenidone, and its regulatory effect on various pulmonary cytokine...