Antifibrotic action of pirfenidone and prednisolone: Different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis - Oku, Hisashi; Shimizu, Toshikatsu; Kawabata, Tomoji; Nagira, Morio; Hikita, Ichiro; Ueyama, Azumi; Matsushima, Shuuichi; Torii, Mikinori; Arimura, Akinori (European journal of pharmacology, 2008)
Keywords: Animals; Basic fibroblast growth factor; Biological and medical sciences; Bleomycin - toxicity; Chemokines - biosynthesis; Cytokines - biosynthesis; Dose-Response Relationship, Drug; Fibroblast Growth Factor 2 - biosynthesis; Intercellular Signaling Peptides and Proteins - biosynthesis; Interferon-gamma - biosynthesis; Interferon-γ; Interleukin-12 Subunit p40 - biosynthesis; Lung - metabolism; Male; Medical sciences; Mice; Mice, Inbred ICR; Pharmacology. Drug treatments; Pirfenidone; Pneumology; Prednisolone; Prednisolone - pharmacology; Prednisolone - therapeutic use; Pulmonary fibrosis; Pulmonary Fibrosis - chemically induced; Pulmonary Fibrosis - drug therapy; Pyridones - pharmacology; Pyridones - therapeutic use; Respiratory system : syndromes and miscellaneous diseases; Transforming Growth Factor beta1 - biosynthesis; Transforming growth factor-β1; Tumor Necrosis Factor-alpha - biosynthesis; Basic fibroblast growth factor; Pulmonary fibrosis; Transforming growth factor-β1; Pirfenidone; Interferon-γ; Prednisolone; Antineoplastic agent; Peptides; Lung; Respiratory system; Antifibrotic agent; Bleomycin; Glycopeptide; Corticosteroid; Lung disease; Respiratory disease; Rodentia; Antiinflammatory agent; Cytokine; Vertebrata; Antibiotic; Mammalia; Mouse; Animal; Adrenal hormone; Transforming growth factor β1; Immunosuppressive agent; Growth factor; Gamma interferon