Association between the Angiotensin-Converting Enzyme (ACE) Genetic Polymorphism and Diabetic Retinopathy—A Meta-Analysis Comprising 10,168 Subjects

• Published in: International journal of environmental research and public health Vol. 13; no. 11; p. 1142
• Main Authors: Luo, Shasha, Shi, Chao, Wang, Furu, Wu, Zhifeng
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 15.11.2016
• Subjects: Adult; Aged; Aged, 80 and over; Asian Continental Ancestry Group - genetics; Diabetes Mellitus, Type 2 - genetics; Diabetic Retinopathy - enzymology; Diabetic Retinopathy - genetics; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Male; Middle Aged; Peptidyl-Dipeptidase A - genetics; Polymorphism, Genetic; Prospective Studies; Risk Assessment; polymorphism; ACE I/D; ethnicity; diabetic retinopathy; DM type

Aims—to address the inconclusive findings of the association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism on risk of diabetic retinopathy (DR), a meta-analysis was conducted. Methods—we conducted a meta-analysis on 4252 DR cases and 5916 controls from 40 published stu...