Interaction between cadmium and aromatic DNA adducts in hprt mutagenesis during foetal development

• Published in: Mutagenesis Vol. 20; no. 3; pp. 181 - 185
• Main Authors: Godschalk, Roger, Hogervorst, Janneke, Albering, Harma, Mercelina-Roumans, Patricia, van Schooten, Frederik-Jan, de Haan, Jelte, Kleinjans, Jos
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.05.2005; Oxford Publishing Limited (England)
• Subjects: Atomic absorption spectroscopy; Biological and medical sciences; Cadmium; Cadmium - blood; Cadmium - toxicity; Deoxyribonucleic acid; DNA; DNA Adducts - blood; DNA Repair - drug effects; DNA Repair - genetics; Female; Fetal Blood - chemistry; Fetal Development - drug effects; Fetal Development - genetics; Fundamental and applied biological sciences. Psychology; Genes, Reporter; Heavy metals; Humans; Hypoxanthine Phosphoribosyltransferase - genetics; Infant, Newborn; Lymphocytes; Lymphocytes - chemistry; Lymphocytes - enzymology; Maternal-Fetal Exchange - drug effects; Maternal-Fetal Exchange - physiology; Metals, Heavy - blood; Metals, Heavy - toxicity; Molecular and cellular biology; Molecular genetics; Mutagenesis; Mutagenesis. Repair; Mutation; Neonates; Pregnancy; Smoking; Smoking - metabolism; Spectral analysis; Spectrometry; Synergistic effect; Xenobiotics; Cadmium; Mutagenesis; Enzyme; Transferases; Glycosyltransferases; Development; Hypoxanthine phosphoribosyltransferase; Pentosyltransferases; Molecular adduct
• ISSN: 0267-8357; 1464-3804
• DOI: 10.1093/mutage/gei022

The foetus is exposed to multiple xenobiotics through the mother's circulation and this is possibly involved in the development of diseases in later life. Heavy metals and lipophilic genotoxins in umbilical cord blood of newborns may have synergistic effects on mutagenesis in the hypoxanthine-p...