The protection of bisphenol A-modulated miRNAs and targets by natural products

• Published in: Environment international Vol. 196; p. 109299
• Main Authors: Chuang, Ya-Ting, Yen, Ching-Yu, Liu, Wangta, Chien, Tsu-Ming, Chang, Fang-Rong, Tsai, Yi-Hong, Tang, Jen-Yang, Chang, Hsueh-Wei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.02.2025; Elsevier
• Subjects: antioxidants; Benzhydryl Compounds - toxicity; bioinformatics; Biological Products - pharmacology; Bisphenol A; Bisphenol A Compounds; Endocrine Disruptors - toxicity; environment; Environmental Pollutants - toxicity; health services; Humans; microRNA; MicroRNAs - metabolism; miRNAs; Natural products; Oxidative stress; Phenols - toxicity; pollutants; protein-protein interactions; STRING; Targets; toxicity; Bisphenol A; Oxidative stress; STRING; Targets; miRNAs; Natural products
• ISSN: 0160-4120; 1873-6750; 1873-6750
• DOI: 10.1016/j.envint.2025.109299

[Display omitted] •Humans face the inevitable exposure of endocrine-disrupting bisphenol A (BPA).•Targets/miRNAs are controlled by BPA but lack a protective link to natural products.•This review classifies BPA-down-/up-regulated targets in the network.•Natural products are innovatively integrated into BPA-modulated miRNAs and targets.•A novel BPA-modulated target-miRNA-protecting natural product axis is explored. Bisphenol A (BPA) is a ubiquitous environmental pollutant with endocrine-disrupting functions. Identifying protective drugs and exploring the mechanisms against BPA are crucial in healthcare. Natural products exhibiting antioxidant properties are considered to be able to protect against BPA toxicity. Although BPA-modulated targets and miRNAs have been individually reported, their connections to natural products were rarely organized. With the help of a protein–protein interaction database (STRING), the relationship between individual BPA-modulated targets was interconnected to provide a systemic view. In this review, BPA-downregulated and -upregulated targets are classified, and their interactive network was innovatively analyzed using the bioinformatic database (STRING). BPA-modulated miRNAs were also retrieved and ingeniously connected to BPA-modulated targets. Moreover, a novel connection between BPA-countering natural products was integrated into BPA-modulated miRNAs and targets. All these targets-associated natural products and/or miRNAs were incorporated into the STRING network, providing systemic relationships. Overall, the BPA-modulated target–miRNA-protecting natural product axis was innovatively constructed, providing a straightforward direction for exploring the integrated BPA-countering effects and mechanisms of natural products.