MicroRNA-23a and MicroRNA-27a Mimic Exercise by Ameliorating CKD-Induced Muscle Atrophy

• Published in: Journal of the American Society of Nephrology Vol. 28; no. 9; pp. 2631 - 2640
• Main Authors: Wang, Bin, Zhang, Cong, Zhang, Aiqing, Cai, Hui, Price, S. Russ, Wang, Xiaonan H.
• Format: Journal Article
• Language: English
• Published: United States American Society of Nephrology 01.09.2017
• Subjects: Animals; Atrophy - etiology; Atrophy - genetics; Atrophy - metabolism; Atrophy - prevention & control; Basic Research; Caspase 3 - metabolism; Caspase 7 - metabolism; Cytokines - genetics; Forkhead Box Protein O1 - metabolism; Mice; MicroRNAs - genetics; MicroRNAs - metabolism; Muscle Proteins - metabolism; Muscle Strength; Muscle, Skeletal - drug effects; Muscle, Skeletal - pathology; Myostatin - metabolism; Phosphorylation; Physical Conditioning, Animal - physiology; Proto-Oncogene Proteins c-akt - metabolism; PTEN Phosphohydrolase - metabolism; Renal Insufficiency, Chronic - complications; RNA, Messenger - metabolism; Signal Transduction; SKP Cullin F-Box Protein Ligases - metabolism; Smad2 Protein - metabolism; Smad3 Protein - metabolism; Transduction, Genetic; Tripartite Motif Proteins - metabolism; Ubiquitin-Protein Ligases - metabolism; uremia; microRNA; TRIM63/MuRF1; exosome; FBXO32/atrogin

Muscle atrophy is a frequent complication of CKD, and exercise can attenuate the process. This study investigated the role of microRNA-23a (miR-23a) and miR-27a in the regulation of muscle mass in mice with CKD. These miRs are located in a gene cluster that is regulated by the transcription factor N...