Zileuton ameliorates depressive-like behaviors, hippocampal neuroinflammation, apoptosis and synapse dysfunction in mice exposed to chronic mild stress

• Published in: International immunopharmacology Vol. 78; p. 105947
• Main Authors: Liu, Cai-Hong, Tan, Yuan-Zhi, Li, Dan-Dan, Tang, Su-Su, Wen, Xiao-An, Long, Yan, Sun, Hong-Bin, Hong, Hao, Hu, Mei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2020; Elsevier BV
• Subjects: 5LO; Abnormalities; Apoptosis; Arachidonate 5-lipoxygenase; Bax protein; Bcl-2 protein; Caspase-3; CMS; Depression; Hippocampus; IL-1β; Inflammation; Lipopolysaccharides; Lipoxygenase; Neurogenesis; Neuroinflammation; NF-κB protein; Postsynaptic density proteins; Stress; Tumor necrosis factor-α; DG; SSRIs; FST; CMS; TBST; Depression; Neuroinflammation; SYN; CNS; NF-κB p65; IL-1β; MDD; Neurogenesis; LPS; TUNEL; TST; TNF-α; NSFT; SNRIs; 5LO

•Zileuton alleviates CMS-induced depressive-like behaviors.•Zileuton represses hippocampal neuroinflammation and apoptosis in the context of depression.•Zileuton promotes hippocampal neurogenesis in the context of depression. Our previous study has found that zileuton, a selective 5-lipoxygenase (5L...