Structural insights for neutralization of Omicron variants BA.1, BA.2, BA.4, and BA.5 by a broadly neutralizing SARS-CoV-2 antibody

• Published in: Science advances Vol. 8; no. 40; p. eadd2032
• Main Authors: Kumar, Sanjeev, Patel, Anamika, Lai, Lilin, Chakravarthy, Chennareddy, Valanparambil, Rajesh, Reddy, Elluri Seetharami, Gottimukkala, Kamalvishnu, Davis-Gardner, Meredith E., Edara, Venkata Viswanadh, Linderman, Susanne, Nayak, Kaustuv, Dixit, Kritika, Sharma, Pragati, Bajpai, Prashant, Singh, Vanshika, Frank, Filipp, Cheedarla, Narayanaiah, Verkerke, Hans P., Neish, Andrew S., Roback, John D., Mantus, Grace, Goel, Pawan Kumar, Rahi, Manju, Davis, Carl W., Wrammert, Jens, Godbole, Sucheta, Henry, Amy R., Douek, Daniel C., Suthar, Mehul S., Ahmed, Rafi, Ortlund, Eric, Sharma, Amit, Murali-Krishna, Kaja, Chandele, Anmol
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 07.10.2022
• Subjects: Angiotensin-Converting Enzyme 2; Antibodies, Monoclonal - chemistry; Antibodies, Viral; Biomedicine and Life Sciences; Coronavirus; COVID-19; Epitopes; Humans; Neutralization Tests; SARS-CoV-2 - genetics; SciAdv r-articles; Spike Glycoprotein, Coronavirus

In this study, by characterizing several human monoclonal antibodies (mAbs) isolated from single B cells of the COVID-19–recovered individuals in India who experienced ancestral Wuhan strain (WA.1) of SARS-CoV-2 during early stages of the pandemic, we found a receptor binding domain (RBD)–specific m...