Rhodium-catalyzed, P-directed selective C7 arylation of indoles

• Published in: Science advances Vol. 4; no. 12; p. eaau6468
• Main Authors: Qiu, Xiaodong, Deng, Hong, Zhao, Yue, Shi, Zhuangzhi
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 01.12.2018
• Subjects: Chemistry; Organic Chemistry; SciAdv r-articles

The indole scaffold will continue to play a vital role in the future of drug discovery and agrochemical development. Regioselective direct arylation of indoles on the benzenoid moiety is a challenging task due to the inherent reactivity of the C2 and C3 positions. Here, we have developed an effectiv...