Clinical Comparison of 99mTc Exametazime and 123I Ioflupane SPECT in Patients with Chronic Mild Traumatic Brain Injury

• Published in: PloS one Vol. 9; no. 1; p. e87009
• Main Authors: Newberg, Andrew B., Serruya, Mijail, Gepty, Andrew, Intenzo, Charles, Lewis, Todd, Amen, Daniel, Russell, David S., Wintering, Nancy
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 2014; Public Library of Science (PLoS)
• Subjects: Abnormalities; Adolescent; Adult; Aged; Binding; Biology; Blood; Blood flow; Brain; Brain Injuries - diagnosis; Brain Injuries - metabolism; Brain Injuries - physiopathology; Cerebral blood flow; Computed tomography; Cortex; Dopamine; Dopamine Plasma Membrane Transport Proteins - metabolism; Dopamine transporter; Emission analysis; Female; Frontal lobe; Frontal Lobe - blood supply; Frontal Lobe - injuries; Frontal Lobe - metabolism; Frontal Lobe - physiopathology; Head injuries; Headache; Headaches; Humans; Integrative medicine; Male; Medical imaging; Medicine; Mental disorders; Mental health; Middle Aged; Migraine; Neostriatum; NMR; Nortropanes; Nuclear magnetic resonance; Pain; Parietal lobe; Patients; Perfusion; Photon emission; Physiology; Protein Binding; Psychiatry; Radiopharmaceuticals; Researchers; Single photon emission computed tomography; Studies; Technetium isotopes; Technetium Tc 99m Exametazime; Temporal lobe; Temporal Lobe - blood supply; Temporal Lobe - injuries; Temporal Lobe - metabolism; Temporal Lobe - physiopathology; Tomography, Emission-Computed, Single-Photon - methods; Traumatic brain injury; United States > US; Connecticut; Pennsylvania

This study evaluated the clinical interpretations of single photon emission computed tomography (SPECT) using a cerebral blood flow and a dopamine transporter tracer in patients with chronic mild traumatic brain injury (TBI). The goal was to determine how these two different scan might be used and c...