Reconstitution of the gut microbiota of antibiotic-treated patients by autologous fecal microbiota transplant

• Published in: Science translational medicine Vol. 10; no. 460
• Main Authors: Taur, Ying, Coyte, Katharine, Schluter, Jonas, Robilotti, Elizabeth, Figueroa, Cesar, Gjonbalaj, Mergim, Littmann, Eric R, Ling, Lilan, Miller, Liza, Gyaltshen, Yangtsho, Fontana, Emily, Morjaria, Sejal, Gyurkocza, Boglarka, Perales, Miguel-Angel, Castro-Malaspina, Hugo, Tamari, Roni, Ponce, Doris, Koehne, Guenther, Barker, Juliet, Jakubowski, Ann, Papadopoulos, Esperanza, Dahi, Parastoo, Sauter, Craig, Shaffer, Brian, Young, James W, Peled, Jonathan, Meagher, Richard C, Jenq, Robert R, van den Brink, Marcel R M, Giralt, Sergio A, Pamer, Eric G, Xavier, Joao B
• Format: Journal Article
• Language: English
• Published: United States 26.09.2018
• Subjects: Anti-Bacterial Agents - pharmacology; Biodiversity; Fecal Microbiota Transplantation; Gastrointestinal Microbiome - drug effects; Hematopoietic Stem Cell Transplantation; Humans; Longitudinal Studies; Transplantation, Autologous

Antibiotic treatment can deplete the commensal bacteria of a patient's gut microbiota and, paradoxically, increase their risk of subsequent infections. In allogeneic hematopoietic stem cell transplantation (allo-HSCT), antibiotic administration is essential for optimal clinical outcomes but sig...