Reconstitution of the gut microbiota of antibiotic-treated patients by autologous fecal microbiota transplant
Antibiotic treatment can deplete the commensal bacteria of a patient's gut microbiota and, paradoxically, increase their risk of subsequent infections. In allogeneic hematopoietic stem cell transplantation (allo-HSCT), antibiotic administration is essential for optimal clinical outcomes but sig...
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| Published in | Science translational medicine Vol. 10; no. 460 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
26.09.2018
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| Subjects | |
| Online Access | Get more information |
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| Abstract | Antibiotic treatment can deplete the commensal bacteria of a patient's gut microbiota and, paradoxically, increase their risk of subsequent infections. In allogeneic hematopoietic stem cell transplantation (allo-HSCT), antibiotic administration is essential for optimal clinical outcomes but significantly disrupts intestinal microbiota diversity, leading to loss of many beneficial microbes. Although gut microbiota diversity loss during allo-HSCT is associated with increased mortality, approaches to reestablish depleted commensal bacteria have yet to be developed. We have initiated a randomized, controlled clinical trial of autologous fecal microbiota transplantation (auto-FMT) versus no intervention and have analyzed the intestinal microbiota profiles of 25 allo-HSCT patients (14 who received auto-FMT treatment and 11 control patients who did not). Changes in gut microbiota diversity and composition revealed that the auto-FMT intervention boosted microbial diversity and reestablished the intestinal microbiota composition that the patient had before antibiotic treatment and allo-HSCT. These results demonstrate the potential for fecal sample banking and posttreatment remediation of a patient's gut microbiota after microbiota-depleting antibiotic treatment during allo-HSCT. |
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| AbstractList | Antibiotic treatment can deplete the commensal bacteria of a patient's gut microbiota and, paradoxically, increase their risk of subsequent infections. In allogeneic hematopoietic stem cell transplantation (allo-HSCT), antibiotic administration is essential for optimal clinical outcomes but significantly disrupts intestinal microbiota diversity, leading to loss of many beneficial microbes. Although gut microbiota diversity loss during allo-HSCT is associated with increased mortality, approaches to reestablish depleted commensal bacteria have yet to be developed. We have initiated a randomized, controlled clinical trial of autologous fecal microbiota transplantation (auto-FMT) versus no intervention and have analyzed the intestinal microbiota profiles of 25 allo-HSCT patients (14 who received auto-FMT treatment and 11 control patients who did not). Changes in gut microbiota diversity and composition revealed that the auto-FMT intervention boosted microbial diversity and reestablished the intestinal microbiota composition that the patient had before antibiotic treatment and allo-HSCT. These results demonstrate the potential for fecal sample banking and posttreatment remediation of a patient's gut microbiota after microbiota-depleting antibiotic treatment during allo-HSCT. |
| Author | Ling, Lilan Giralt, Sergio A Xavier, Joao B Perales, Miguel-Angel Ponce, Doris Meagher, Richard C Shaffer, Brian Figueroa, Cesar Castro-Malaspina, Hugo Koehne, Guenther Barker, Juliet van den Brink, Marcel R M Jenq, Robert R Miller, Liza Sauter, Craig Papadopoulos, Esperanza Peled, Jonathan Coyte, Katharine Littmann, Eric R Gjonbalaj, Mergim Jakubowski, Ann Pamer, Eric G Fontana, Emily Morjaria, Sejal Dahi, Parastoo Young, James W Gyaltshen, Yangtsho Robilotti, Elizabeth Schluter, Jonas Tamari, Roni Gyurkocza, Boglarka Taur, Ying |
| Author_xml | – sequence: 1 givenname: Ying orcidid: 0000-0002-6601-8284 surname: Taur fullname: Taur, Ying organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 2 givenname: Katharine orcidid: 0000-0002-5231-9350 surname: Coyte fullname: Coyte, Katharine organization: Division of Infectious Diseases and Division of Gastroenterology, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA – sequence: 3 givenname: Jonas surname: Schluter fullname: Schluter, Jonas organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 4 givenname: Elizabeth surname: Robilotti fullname: Robilotti, Elizabeth organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 5 givenname: Cesar surname: Figueroa fullname: Figueroa, Cesar organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 6 givenname: Mergim surname: Gjonbalaj fullname: Gjonbalaj, Mergim organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 7 givenname: Eric R orcidid: 0000-0002-8233-9256 surname: Littmann fullname: Littmann, Eric R organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 8 givenname: Lilan surname: Ling fullname: Ling, Lilan organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 9 givenname: Liza orcidid: 0000-0001-6488-451X surname: Miller fullname: Miller, Liza organization: Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA – sequence: 10 givenname: Yangtsho orcidid: 0000-0001-8638-2078 surname: Gyaltshen fullname: Gyaltshen, Yangtsho organization: American Museum of Natural History, New York, NY 10024, USA – sequence: 11 givenname: Emily surname: Fontana fullname: Fontana, Emily organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 12 givenname: Sejal orcidid: 0000-0001-7956-1385 surname: Morjaria fullname: Morjaria, Sejal organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 13 givenname: Boglarka orcidid: 0000-0002-2933-2119 surname: Gyurkocza fullname: Gyurkocza, Boglarka organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 14 givenname: Miguel-Angel surname: Perales fullname: Perales, Miguel-Angel organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 15 givenname: Hugo orcidid: 0000-0002-9956-904X surname: Castro-Malaspina fullname: Castro-Malaspina, Hugo organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 16 givenname: Roni surname: Tamari fullname: Tamari, Roni organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 17 givenname: Doris surname: Ponce fullname: Ponce, Doris organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 18 givenname: Guenther surname: Koehne fullname: Koehne, Guenther organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 19 givenname: Juliet orcidid: 0000-0001-6693-0911 surname: Barker fullname: Barker, Juliet organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 20 givenname: Ann surname: Jakubowski fullname: Jakubowski, Ann organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 21 givenname: Esperanza surname: Papadopoulos fullname: Papadopoulos, Esperanza organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 22 givenname: Parastoo surname: Dahi fullname: Dahi, Parastoo organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 23 givenname: Craig surname: Sauter fullname: Sauter, Craig organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 24 givenname: Brian surname: Shaffer fullname: Shaffer, Brian organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 25 givenname: James W orcidid: 0000-0002-0032-6559 surname: Young fullname: Young, James W organization: Rockefeller University, New York, NY 10065, USA – sequence: 26 givenname: Jonathan orcidid: 0000-0002-4029-7625 surname: Peled fullname: Peled, Jonathan organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 27 givenname: Richard C orcidid: 0000-0001-6230-9140 surname: Meagher fullname: Meagher, Richard C organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 28 givenname: Robert R orcidid: 0000-0002-5434-439X surname: Jenq fullname: Jenq, Robert R organization: University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA – sequence: 29 givenname: Marcel R M orcidid: 0000-0003-0696-4401 surname: van den Brink fullname: van den Brink, Marcel R M organization: Weill Cornell Medical College, New York, NY 10065, USA – sequence: 30 givenname: Sergio A orcidid: 0000-0003-1944-5053 surname: Giralt fullname: Giralt, Sergio A organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – sequence: 31 givenname: Eric G orcidid: 0000-0002-6755-9904 surname: Pamer fullname: Pamer, Eric G email: pamere@mskcc.org, xavierj@mskcc.org organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. pamere@mskcc.org xavierj@mskcc.org – sequence: 32 givenname: Joao B surname: Xavier fullname: Xavier, Joao B email: pamere@mskcc.org, xavierj@mskcc.org organization: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. pamere@mskcc.org xavierj@mskcc.org |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30257956$$D View this record in MEDLINE/PubMed |
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| PublicationDate | 2018-09-26 |
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| PublicationTitle | Science translational medicine |
| PublicationTitleAlternate | Sci Transl Med |
| PublicationYear | 2018 |
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| Snippet | Antibiotic treatment can deplete the commensal bacteria of a patient's gut microbiota and, paradoxically, increase their risk of subsequent infections. In... |
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| SubjectTerms | Anti-Bacterial Agents - pharmacology Biodiversity Fecal Microbiota Transplantation Gastrointestinal Microbiome - drug effects Hematopoietic Stem Cell Transplantation Humans Longitudinal Studies Transplantation, Autologous |
| Title | Reconstitution of the gut microbiota of antibiotic-treated patients by autologous fecal microbiota transplant |
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| Volume | 10 |
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