CENP-O, a protein localized at the centromere throughout the cell cycle, is a novel target antigen in systemic sclerosis

• Published in: Journal of rheumatology Vol. 36; no. 4; p. 781
• Main Authors: Saito, Akiko, Muro, Yoshinao, Sugiura, Kazumitsu, Ikeno, Masashi, Yoda, Kinya, Tomita, Yasushi
• Format: Journal Article
• Language: English
• Published: Canada 01.04.2009
• Subjects: Adult; Aged; Antigens - immunology; Autoantibodies - immunology; Cell Cycle - physiology; Centromere - metabolism; Chromosomal Proteins, Non-Histone - immunology; DNA-Binding Proteins - immunology; Female; HeLa Cells; Humans; Middle Aged; Scleroderma, Systemic - immunology; Scleroderma, Systemic - physiopathology

CENP-A, -B, and -C are major centromere components and the main targets of anticentromere antibodies (ACA). Many other proteins are also assembled around CENP-A nucleosomes in interphase nuclei to form the interphase centromere complex (ICEN). The CENP-O protein is a component of the ICEN that local...