Autologous Mesenchymal Stem Cells Increase Cortical Perfusion in Renovascular Disease

• Published in: Journal of the American Society of Nephrology Vol. 28; no. 9; pp. 2777 - 2785
• Main Authors: Saad, Ahmed, Dietz, Allan B., Herrmann, Sandra M.S., Hickson, LaTonya J., Glockner, James F., McKusick, Michael A., Misra, Sanjay, Bjarnason, Haraldur, Armstrong, Adam S., Gastineau, Dennis A., Lerman, Lilach O., Textor, Stephen C.
• Format: Journal Article
• Language: English
• Published: United States American Society of Nephrology 01.09.2017
• Subjects: Aged; Angiotensin Receptor Antagonists - therapeutic use; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Atherosclerosis - physiopathology; Atherosclerosis - therapy; Clinical Research; Female; Glomerular Filtration Rate; Humans; Hypoxia - therapy; Infusions, Intra-Arterial; Kidney - blood supply; Kidney - diagnostic imaging; Kidney - physiopathology; Magnetic Resonance Imaging; Male; Mesenchymal Stem Cell Transplantation - adverse effects; Multidetector Computed Tomography; Oxygen - blood; Renal Artery Obstruction - physiopathology; Renal Artery Obstruction - therapy; Renal Circulation; Transplantation, Autologous; Vascular Endothelial Growth Factor A - blood; Vascular Endothelial Growth Factor C - blood; Renovascular disease; renal artery stenosis; stem cell; ischemia

Atherosclerotic renovascular disease (RVD) reduces renal blood flow (RBF) and GFR and accelerates poststenotic kidney (STK) tissue injury. Preclinical studies indicate that mesenchymal stem cells (MSCs) can stimulate angiogenesis and modify immune function in experimental RVD. We assessed the safety...