Selective downregulation of natural killer activating receptors on NK cells and upregulation of PD-1 expression on T cells in children with severe and/or recurrent Herpes simplex virus infections

• Published in: Immunobiology (1979) Vol. 226; no. 3; p. 152097
• Main Authors: Lenart, Marzena, Kluczewska, Anna, Szaflarska, Anna, Rutkowska-Zapała, Magdalena, Wąsik, Magdalena, Ziemiańska-Pięta, Anna, Kobylarz, Krzysztof, Pituch-Noworolska, Anna, Siedlar, Maciej
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier GmbH 01.05.2021
• Subjects: Checkpoint molecules; Child; Child, Preschool; Female; Gene Expression Regulation; Herpes Simplex - diagnosis; Herpes Simplex - etiology; Herpes Simplex - metabolism; Host-Pathogen Interactions - genetics; Host-Pathogen Interactions - immunology; HSV; Humans; Immunophenotyping; Killer Cells, Natural - immunology; Killer Cells, Natural - metabolism; Lymphocyte Activation; Lymphocyte Count; Male; NK cell activating receptors; NK cells; PD-1; Programmed Cell Death 1 Receptor - genetics; Programmed Cell Death 1 Receptor - metabolism; Receptors, Natural Cytotoxicity Triggering - genetics; Receptors, Natural Cytotoxicity Triggering - metabolism; Recurrence; Severity of Illness Index; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism; NK cells; HSV; Checkpoint molecules; NK cell activating receptors; PD-1

•NK cells expressing activating receptors (CD16, NKp46, NKp80, NKG2D and 2B4) and/or expression of these receptors was selectively downregulated in children with severe and/or recurrent HSV infection;•NTB-A receptor expression was upregulated on patients’ CD16dimCD56bright NK cells and CD8+ T cell s...