IL6 −174 G/C Promoter Polymorphism Influences Susceptibility to Mucosal but Not Localized Cutaneous Leishmaniasis in Brazil

• Published in: The Journal of infectious diseases Vol. 194; no. 4; pp. 519 - 527
• Main Authors: Castellucci, Léa, Menezes, Eliane, Oliveira, Joyce, Magalhães, Andrea, Guimarães, Luiz Henrique, Lessa, Marcus, Ribeiro, Silvana, Reale, Jeancarlo, Noronha, Elza Ferreira, Wilson, Mary E., Duggal, Priya, Beaty, Terri H., Jeronimo, Selma, Jamieson, Sarra E., Bales, Ashlee, Blackwell, Jenefer M., de Jesus, Amélia Ribeiro, Carvalho, Edgar M.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 15.08.2006; University of Chicago Press
• Subjects: Adult; Alleles; Animals; Biological and medical sciences; Brazil - epidemiology; Case-Control Studies; Cutaneous leishmaniasis; Cytokines; Female; Fundamental and applied biological sciences. Psychology; Genes; Genotypes; Housing; Humans; Infections; Infectious diseases; Interleukin-6 - biosynthesis; Interleukin-6 - genetics; Interleukins; Leishmania braziliensis; Leishmaniasis; Leishmaniasis, Cutaneous - epidemiology; Leishmaniasis, Cutaneous - etiology; Leishmaniasis, Cutaneous - genetics; Leishmaniasis, Cutaneous - immunology; Leishmaniasis, Cutaneous - pathology; Macrophages; Male; Medical sciences; Microbiology; Middle Aged; Mucous Membrane; Parasites; Polymorphism, Genetic; Promoter Regions, Genetic - genetics; Risk Factors; T lymphocytes; South America; Brazil; America; Infection; Interleukin 6; Cutaneous leishmaniasis; Skin disease; Protozoal disease; Sensitivity; Microbiology; Mucosa; Cytokine; Parasitosis; Polymorphism

BackgroundMucosal leishmaniasis (ML) is associated with exaggerated tumor necrosis factor–α and interferon-γ responses and tissue destruction. ML follows localized cutaneous leishmaniasis (CL) caused by Leishmania braziliensis infection. Interleukin (IL)–6 down-regulates T helper (Th) cell type 1 di...