An RNA-binding protein, Qki5, regulates embryonic neural stem cells through pre-mRNA processing in cell adhesion signaling

• Published in: Genes & development Vol. 31; no. 18; pp. 1910 - 1925
• Main Authors: Hayakawa-Yano, Yoshika, Suyama, Satoshi, Nogami, Masahiro, Yugami, Masato, Koya, Ikuko, Furukawa, Takako, Zhou, Li, Abe, Manabu, Sakimura, Kenji, Takebayashi, Hirohide, Nakanishi, Atsushi, Okano, Hideyuki, Yano, Masato
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 15.09.2017
• Subjects: Alternative Splicing - physiology; Animals; Brain - embryology; Cell Adhesion - physiology; Cell Communication; Down-Regulation; Gene Expression Profiling; Mice; Mice, Knockout; Mouse Embryonic Stem Cells - metabolism; Neural Stem Cells - metabolism; Neurogenesis - genetics; Neurogenesis - physiology; Protein Isoforms - genetics; Protein Isoforms - metabolism; Research Paper; RNA Precursors - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Signal Transduction; HITS-CLIP; RNA-binding protein; neural stem cell; alternative splicing; quaking; cell adhesion

Cell type-specific transcriptomes are enabled by the action of multiple regulators, which are frequently expressed within restricted tissue regions. In the present study, we identify one such regulator, Quaking 5 (Qki5), as an RNA-binding protein (RNABP) that is expressed in early embryonic neural s...