Construction of a pH-responsive, ultralow-dose triptolide nanomedicine for safe rheumatoid arthritis therapy - Liu, Yang; Jin, Jianqiu; Xu, Hao; Wang, Chao; Yang, Yanping; Zhao, Yongjian; Han, Haihui; Hou, Tong; Yang, Guoliang; Zhang, Li; Wang, Yongjun; Zhang, Weian; et al. (Acta biomaterialia, 2021)
Keywords: Animals; Apoptosis; Arthritis; Arthritis, Rheumatoid - drug therapy; Autoimmune diseases; Biocompatibility; Block copolymers; Cartilage; Collagen; Cytotoxicity; Diterpenes; Epoxy Compounds; Hydrogen-Ion Concentration; Hyperplasia; Inflammation; Intravenous administration; Mice; Nanomedicine; Nanotechnology; pH effects; Pharmacodynamics; Pharmacokinetics; Pharmacology; Phenanthrenes - pharmacology; POSS-PCL-b-PDMAEMA; Rheumatoid arthritis; Toxicity; Triptolide; Rheumatoid arthritis; Triptolide; POSS-PCL-b-PDMAEMA