Primum non nocere – The effects of sodium hypochlorite on dentin as used in endodontics

• Published in: Acta biomaterialia Vol. 61; pp. 144 - 156
• Main Authors: Gu, Li-sha, Huang, Xue-qing, Griffin, Brandon, Bergeron, Brian R., Pashley, David H., Niu, Li-na, Tay, Franklin R.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2017; Elsevier BV
• Subjects: Amino Acids - analysis; Antiinfectives and antibacterials; Apatite; Calcification, Physiologic - drug effects; Chromatography; Chromatography, Ion Exchange; Collagen; Collagen - metabolism; Collagen degradation; Compartments; Dentin; Dentin - drug effects; Dentin - ultrastructure; Dissolution; Electron microscopy; Endodontics; Enzyme-Linked Immunosorbent Assay; Fibrils; Flexural strength; Fourier transforms; Health care; Humans; Infrared spectroscopy; Integrity; Mineralization; Molecular weight; Oxidation; Oxidizing agents; Root canals; Size congruity; Size exclusion chromatography; Sodium; Sodium hypochlorite; Sodium Hypochlorite - pharmacology; Spectroscopy, Fourier Transform Infrared; Transmission electron microscopy; Tubules; Dentin; Sodium hypochlorite; Size congruity; Collagen degradation; Flexural strength

[Display omitted] The medical literature is replete with the maxim ‘primum non nocere’, cautioning health care providers to avoid doing any harm to human subjects in their delivery of medical care. Sodium hypochlorite (NaOCl) is a well-established irrigant for root canal treatment because of its ant...