Topical transport of hydrophilic compounds using water-in-oil nanoemulsions

• Published in: International journal of pharmaceutics Vol. 220; no. 1; pp. 63 - 75
• Main Authors: Wu, Huailiang, Ramachandran, Chandrasekharan, Weiner, Norman D, Roessler, Blake J
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 04.06.2001; Elsevier
• Subjects: Administration, Topical; Animals; Biological and medical sciences; Biological Transport - drug effects; Chemistry, Pharmaceutical; Emulsions - pharmacology; General pharmacology; HLB; Hydrophilic drug; Inulin - administration & dosage; Inulin - pharmacokinetics; Linear Models; Male; Medical sciences; Mice; Mice, Inbred ICR; Nanoemulsions; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Rats; Rats, Sprague-Dawley; Sebum; Skin Absorption - drug effects; Skin transport; Species Specificity; Transfollicular; Skin transport; Nanoemulsions; Hydrophilic drug; Sebum; Transfollicular; HLB; Water oil emulsion; Rat; Biological transport; Drug carrier; Strain specificity; Surfactant; Molecular weight; Ethylene oxide polymer; Hydrophilic lipophilic balance; Formulation; Inulin; Hydrophilic compound; Diffusion; Pharmaceutical technology; Non ionic surfactant; Rodentia; Permeation; Olive oil; In vitro; Vertebrata; Mammalia; Mouse; Animal; Dosage form; Sorbitan oleate; Skin; Physicochemical properties; Topical administration

A variety of water-in-oil nanoemulsions were prepared using sorbitan monooleate (Span®80), polyoxyethylene 20 sorbitan monooleate (Tween®80), olive oil and water. The nanoemulsions were tested for their ability to facilitate transport of a model hydrophilic solute, inulin, across hairless and hairy...