FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity - Wang, Xiaoxin X.; Wang, Dong; Luo, Yuhuan; Myakala, Komuraiah; Dobrinskikh, Evgenia; Rosenberg, Avi Z.; Levi, Jonathan; Kopp, Jeffrey B.; Field, Amanda; Hill, Ashley; Lucia, Scott; Qiu, Liru; et al. (Journal of the American Society of Nephrology, 2018)
Keywords: Albuminuria - etiology; Animals; Basic Research; Bile Acids and Salts - pharmacology; Chenodeoxycholic Acid - analogs & derivatives; Chenodeoxycholic Acid - pharmacology; Cholesterol - metabolism; Cholic Acids - pharmacology; Diabetes Mellitus, Experimental - complications; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Type 2 - metabolism; Diabetic Nephropathies - complications; Diabetic Nephropathies - metabolism; Diabetic Nephropathies - pathology; Diabetic Nephropathies - prevention & control; Disease Progression; Endoplasmic Reticulum Stress; Fibrosis; Glomerular Mesangium - pathology; Humans; Kidney Tubules - pathology; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mitochondria - metabolism; Obesity - complications; Obesity - metabolism; Oxidative Stress; Podocytes - pathology; Receptors, Cytoplasmic and Nuclear - agonists; Receptors, Cytoplasmic and Nuclear - genetics; Receptors, Cytoplasmic and Nuclear - metabolism; Receptors, G-Protein-Coupled - agonists; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; RNA, Messenger - metabolism; Signal Transduction - drug effects; Triglycerides - metabolism; metabolism; diabetic nephropathy; obesity