Glutathione peroxidase 3, a new retinoid target gene, is crucial for human skeletal muscle precursor cell survival

• Published in: Journal of cell science Vol. 125; no. Pt 24; pp. 6147 - 6156
• Main Authors: El Haddad, Marina, Jean, Elise, Turki, Ahmed, Hugon, Gérald, Vernus, Barbara, Bonnieu, Anne, Passerieux, Emilie, Hamade, Aline, Mercier, Jacques, Laoudj-Chenivesse, Dalila, Carnac, Gilles
• Format: Journal Article
• Language: English
• Published: England Company of Biologists 15.12.2012
• Subjects: Adult; Animals; Antioxidants - pharmacology; Apoptosis; Cell Survival - drug effects; Cell Survival - genetics; Cells, Cultured; Gene Knockdown Techniques; Glutathione Peroxidase - deficiency; Glutathione Peroxidase - genetics; Glutathione Peroxidase - metabolism; Humans; Life Sciences; Mice; Mice, SCID; Myoblasts - cytology; Myoblasts - drug effects; Myoblasts - enzymology; Reactive Oxygen Species - metabolism; Tretinoin - pharmacology; myoblasts; retinoic acid; vitamin A; GPx3; facioscapulohumeral dystrophy (FSHD); transplantation

Protection of satellite cells from cytotoxic damages is crucial to ensure efficient adult skeletal muscle regeneration and to improve therapeutic efficacy of cell transplantation in degenerative skeletal muscle diseases. It is therefore important to identify and characterize molecules and their targ...