Development of a sensitive method for the determination of ganciclovir by reversed-phase high-performance liquid chromatography

• Published in: Journal of Chromatography A Vol. 870; no. 1; pp. 159 - 167
• Main Authors: Merodio, M, Campanero, M.A, Mirshahi, T, Mirshahi, M, Irache, J.M
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 18.02.2000; Elsevier
• Subjects: Acyclovir; Albumin; Analysis; Antiviral Agents - analysis; Biological and medical sciences; Calibration; Cells, Cultured; Chromatography, High Pressure Liquid - methods; Ganciclovir; Ganciclovir - analysis; General pharmacology; Humans; Medical sciences; Nucleoside analogues; Pharmacology. Drug treatments; Reproducibility of Results; Sensitivity and Specificity; Albumin; Ganciclovir; Pharmaceutical analysis; Acyclovir; Nucleoside analogues; Human; Cell culture; Cornea; Acyclic nucleoside; Purine nucleoside; Chemical analysis; Controlled release form; Nanoparticle; Supernatant; HPLC chromatography; Uptake; Eye; Nanometer scale; Reversed phase chromatography; Ultraviolet detector; Dosage form; Antiviral; Fibroblast; Quantitative analysis

Ganciclovir is a nucleoside analogue widely used in the treatment of cytomegalovirus infections, which affects mainly immunocompromised patients. Recently, new pharmaceutical dosage forms based on the use of albumin nanoparticles have been developed for improving the efficacy of this drug. The aim o...