Gastroesophageal reflux disease, acid suppression, and Mycobacterium avium complex pulmonary disease

• Published in: Chest Vol. 131; no. 4; p. 1166
• Main Authors: Thomson, Rachel M, Armstrong, John G, Looke, David F
• Format: Journal Article
• Language: English
• Published: United States 01.04.2007
• Subjects: Adult; Aged; Aged, 80 and over; Antacids - therapeutic use; Enzyme Inhibitors - therapeutic use; Female; Follow-Up Studies; Gastric Acid - metabolism; Gastroesophageal Reflux - complications; Gastroesophageal Reflux - drug therapy; Gastroesophageal Reflux - metabolism; Gastroscopy; Histamine H2 Antagonists - therapeutic use; Humans; Lung Diseases - epidemiology; Lung Diseases - etiology; Lung Diseases - microbiology; Male; Middle Aged; Mycobacterium avium Complex - isolation & purification; Mycobacterium avium-intracellulare Infection - epidemiology; Mycobacterium avium-intracellulare Infection - etiology; Mycobacterium avium-intracellulare Infection - microbiology; Prevalence; Prospective Studies; Proton Pump Inhibitors; Queensland - epidemiology; Sputum - microbiology; Treatment Outcome; Queensland
• ISSN: 0012-3692
• DOI: 10.1378/chest.06-1906

Weekly symptoms of gastroesophageal reflux disease (GERD) occur in 20% of the population, and GERD has been implicated in the pathophysiology of many respiratory diseases. Microaspiration of contaminated water is a potential portal of entry for Mycobacterium avium complex (MAC) organisms into the re...