Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure - Yang, Xinyu; Cheng, Xiaoye; Tang, Yiting; Qiu, Xianhui; Wang, Yupeng; Kang, Haixia; Wu, Jianfeng; Wang, Zhongtai; Liu, Yukun; Chen, Fangping; Xiao, Xianzhong; Mackman, Nigel; et al. (Immunity (Cambridge, Mass.), 2019)
Keywords: Ablation; Animals; Apoptosis; Bacteria; Bacterial infections; Biomarkers; Blood Coagulation - physiology; Blood platelets; Calcium; Calcium influx; Caspase-11; Caspases, Initiator - genetics; Caspases, Initiator - metabolism; Cell activation; Cell death; Cell Line, Tumor; Clonal deletion; Coagulation; Disseminated intravascular coagulation; Disseminated Intravascular Coagulation - pathology; Endotoxemia - pathology; Endotoxins; Enzyme Activation; Exposure; Gram-negative bacteria; HeLa Cells; HT29 Cells; Humans; IL-1β; Infections; Interleukin-1alpha - blood; Interleukin-1beta - blood; Interleukins; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Leukocytes; Lipopolysaccharides; Lipopolysaccharides - metabolism; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Mortality; Neutralization; non-canonical inflammasome; Phosphate-Binding Proteins - genetics; Phosphate-Binding Proteins - metabolism; Phosphatidylserine; phosphatidylserine exposure; Phosphatidylserines - metabolism; Phospholipids; Pores; Proteins; Pyroptosis - physiology; Rodents; Sepsis; Signal Transduction - physiology; Thromboplastin - metabolism; Tissue factor; caspase-11; non-canonical inflammasome; phosphatidylserine exposure; coagulation; sepsis