Phosphoprotein enriched in astrocytes-15 kDa expression inhibits astrocyte migration by a protein kinase C delta-dependent mechanism

• Published in: Molecular biology of the cell Vol. 17; no. 12; pp. 5141 - 5152
• Main Authors: Renault-Mihara, François, Beuvon, Frédéric, Iturrioz, Xavier, Canton, Brigitte, De Bouard, Sophie, Léonard, Nadine, Mouhamad, Shahul, Sharif, Ariane, Ramos, Joe W, Junier, Marie-Pierre, Chneiweiss, Hervé
• Format: Journal Article
• Language: English
• Published: United States American Society for Cell Biology 01.12.2006; The American Society for Cell Biology
• Subjects: Active Transport, Cell Nucleus; Animals; Astrocytes - cytology; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases - metabolism; Cell Movement; Cell Nucleus - metabolism; Cell Proliferation; Chemical Sciences; Extracellular Signal-Regulated MAP Kinases - metabolism; Glioblastoma - pathology; Humans; Intracellular Signaling Peptides and Proteins - metabolism; Life Sciences; Mice; Molecular Weight; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases - metabolism; Phosphoproteins - metabolism; Protein Kinase C-delta - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Rats; Wound Healing - physiology

Phosphoprotein enriched in astrocytes-15 kDa (PEA-15), a phosphoprotein enriched in astrocytes, inhibits both apoptosis and proliferation in normal and cancerous cells. Here, analysis of PEA-15 expression in glioblastoma organotypic cultures revealed low levels of PEA-15 in tumor cells migrating awa...