Regulation of estrogen activity by sulfation in human Ishikawa endometrial adenocarcinoma cells

• Published in: The Journal of steroid biochemistry and molecular biology Vol. 68; no. 3; pp. 137 - 144
• Main Authors: Kotov, Alexander, Falany, Josie L, Wang, Jin, Falany, Charles N
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.02.1999; Elsevier Science
• Subjects: Adenocarcinoma - metabolism; Alkaline Phosphatase - metabolism; Biological and medical sciences; Cytosol - enzymology; Diethylstilbestrol - metabolism; Endometrial adenocarcinoma cells; Endometrial Neoplasms - metabolism; Estrogen; Estrogens - metabolism; Ethinyl Estradiol - metabolism; Female; Fundamental and applied biological sciences. Psychology; Hormone metabolism and regulation; Humans; Ishikawa cells; Kinetics; Mammalian female genital system; Receptors, Estrogen - metabolism; Substrate Specificity; Sulfation; Sulfotransferase; Sulfotransferases - metabolism; Tumor Cells, Cultured; Vertebrates: reproduction; β-estradiol; Endometrial adenocarcinoma cells; β-estradiol; Ishikawa cells; Sulfotransferase; Estrogen; Sulfation; Human; Sulfotransferases; Enzyme; Transferases; 17β-Estradiol; Metabolism; Ovarian hormone; Sulfatation; Cell line; Uterus; Female genital system; Endometrium; Hormonal receptor

Sulfation is an important conjugation reaction in the metabolism of steroids. Steroids sulfates do not interact with the appropriate hormone receptors; additionally, the presence of the charged sulfate moiety increases the aqueous solubility and excretion of most steroids. Estrogen sulfotransferase...