Sexually dimorphic impact of preconceptional and gestational exposure to a real-life environmental chemical mixture (biosolids) on offspring growth dynamics and puberty in sheep

• Published in: Environmental toxicology and pharmacology Vol. 102; p. 104257
• Main Authors: Evans, Neil P., Bellingham, Michelle, Elcombe, Christopher S., Ghasemzadeh-Hasankolaei, Mohammad, Lea, Richard G., Sinclair, Kevin D., Padmanabhan, Vasantha
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2023
• Subjects: Animals; Biosolids; Body Size; Body Weight; Bodyweight; Developmental toxicity; Environmental chemicals; Female; Humans; Male; Pregnancy; Puberty; Reproduction; Sexual Maturation; Sexually dimorphic; Sheep; Puberty; Developmental toxicity; Environmental chemicals; Bodyweight; Sexually dimorphic

Humans are ubiquitously exposed to complex mixtures of environmental chemicals (ECs). This study characterised changes in post-natal and peripubertal growth, and the activation of the reproductive axis, in male and female offspring of sheep exposed to a translationally relevant EC mixture (in biosol...